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Title of Journal: Osteoporos Int

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Abbravation: Osteoporosis International

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Springer-Verlag

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DOI

10.1016/0044-8486(88)90150-0

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1433-2965

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The relationship of vitamin D status to bone miner

Authors: Nazzarena Malavolta Loredana Pratelli Marilena Frigato Rita Mulè Maria Lucia Mascia Saverio Gnudi
Publish Date: 2005/06/15
Volume: 16, Issue: 12, Pages: 1691-1697
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Abstract

Several authors have found a relationship between vitamin D status and bone mineral density BMD To our knowledge no previous studies on this topic have been carried out on the Italian postmenopausal population We studied this relationship retrospectively in 156 Italian postmenopausal women We also investigated the relationship between parathyroid hormone PTH and BMD Measurements of BMD were taken at the lumbar spine and upper femur by dual Xray absorptiometry Serum 25OHD calcidiol 125OH2D calcitriol PTH calcium phosphorus creatinine osteocalcin and urinary calcium and phosphorus were measured according to the current laboratory methods of analysis We found a positive statistically significant correlation between BMD both at the spine and hip and 25OHD and a negative statistically significant correlation between BMD and PTH No statistically significant correlation was found between BMD and 125OH2D Crude logistic regression showed age 25OHD and PTH were significant predictors of low BMD while 125OH2D was not Backward logistic regression showed 25OHD was the best predictive model for spine osteoporosis together with age and on its own it was the best predictive model for femoral neck osteoporosis

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