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Title of Journal: Osteoporos Int

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Abbravation: Osteoporosis International

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Springer-Verlag

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DOI

10.1002/jib.241

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ISSN

1433-2965

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Effects of a combined alendronate and calcitriol a

Authors: Y Rhee M Kang Y Min D Byun Y Chung C Ahn K Baek J Mok D Kim D Kim H Kim Y Kim S Myoung D Kim SK Lim
Publish Date: 2006/09/26
Volume: 17, Issue: 12, Pages: 1801-1807
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Abstract

A total of 217 postmenopausal women with osteoporosis were enrolled 199 patients were randomly assigned to one of two treatment groups Maxmarvil group or alfacalcidol group None of the patients were vitaminDdeficient as assessed by serum 25hydroxyvitamin D 25OHD nor had they received any drugs affecting bone metabolism before enrollment Bone mineral densities BMD of L1–L4 and the femur were measured by dualenergy Xray absorptiometry DXA at the initial assessment and after 6 months of treatment Serum biochemical assays including serum calcium 24h urinary calcium excretion and bone turnover markers both bonespecific alkaline phosphatase bsALP and urine Ntelopeptide NTx were performed at the baseline and after 3 and 6 months of treatmentIn the Maxmarvil group the BMD of the lumbar spine increased up to 242±05 from the baseline after 6 months p005 On the other hand the change in BMD in the alfacalcidol group was 028±05 after 6 months There was no significant difference in femoral BMD between the two groups The levels of bsALP and NTx were significantly lower in the Maxmarvil group than in the alfacalcidol group −2204±39 vs −1142±28 p005 and −2546±52 vs 124±62 p0001 respectively Interestingly there was a significantly smaller amount of 24h urinary calcium in the Maxmarvil group p005

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  4. Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women
  5. Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures
  6. Evaluation of three risk assessment tools in discriminating fracture status among Chinese patients undergoing hemodialysis
  7. Oral bisphosphonates and risk of ischemic stroke: a case–control study
  8. The association between serum osteocalcin levels and metabolic syndrome in Koreans
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  10. Fracture risk and adjuvant hormonal therapy among a population-based cohort of older female breast cancer patients
  11. Cost-utility of long-term strontium ranelate treatment for postmenopausal osteoporotic women
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  13. Genetic analysis of serum osteocalcin and bone mineral in multigenerational Afro-Caribbean families
  14. Effect of hospitalist consultation on treatment of osteoporosis in hip fracture patients
  15. Declining incidence of low-trauma knee fractures in elderly women: nationwide statistics in Finland between 1970 and 2006
  16. Changing health behaviors with social marketing
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