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Title of Journal: Osteoporos Int

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Abbravation: Osteoporosis International

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Springer-Verlag

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DOI

10.1002/chin.198914092

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ISSN

1433-2965

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Results of indirect and mixed treatment comparison

Authors: N Freemantle C Cooper A DiezPerez M Gitlin H Radcliffe S Shepherd C Roux
Publish Date: 2012/07/26
Volume: 24, Issue: 1, Pages: 209-217
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Abstract

Network metaanalysis techniques metaanalysis adjusted indirect comparison and mixed treatment comparison MTC allow for treatment comparisons in the absence of headtohead trials In this study conditional estimates of relative treatment efficacy derived through these techniques show important differences in the fracture risk reduction profiles of marketed pharmacologic therapies for postmenopausal osteoporosisThis study illustrates how network metaanalysis techniques metaanalysis adjusted indirect comparison and MTC can provide comparisons of the relative efficacy of postmenopausal osteoporosis therapies in the absence of comprehensive headtohead trialsSource articles were identified in MEDLINE EMBASE Cochrane Central Register of Controlled Trials CENTRAL via Wiley Interscience and Cumulative Index to Nursing and Allied Health Literature CINAHL between April 28 2009 and November 4 2009 Two reviewers identified Englishlanguage articles reporting randomized controlled trials RCTs with onlabel dosing of marketed osteoporosis agents and fracture endpoints Trial design population characteristics intervention and comparator fracture outcomes and adverse events were abstracted for analysis Primary analyses included data from RCTs with fracture endpoints Sensitivity analyses also included studies with fractures reported through adverse event reports Metaanalysis compared fracture outcomes for pharmacological therapies vs placebo fixed and random effects models adjusted indirect comparisons and MTC assessed fracture risk in postmenopausal women treated with denosumab vs other agentsUsing data from 34 studies random effects metaanalysis showed that all agents except etidronate significantly reduced the risk of new vertebral fractures compared with placebo denosumab risedronate and zoledronic acid significantly reduced the risk for nonvertebral and hip fracture while alendronate strontium ranelate and teriparatide significantly reduced the risk for nonvertebral fractures MTC showed denosumab to be more effective than strontium ranelate raloxifene alendronate and risedronate in preventing new vertebral fracturesThis study was funded by Amgen Inc NF has received research grants from Amgen Inc and has served as a consultant for Amgen Inc SanofiAventis Pfizer Wyeth and Eli Lilly CC has received consulting and lecture fees from Amgen Inc GSK Eli Lilly Novartis Servier and Alliance for Bone Health ADP has received honoraria from or consulted for Amgen Inc Novartis Eli Lilly and MSD and received research grants from the Alliance of Bone Health and Amgen Inc CR has received research grants and/or honoraria from Amgen MSD Servier Novartis and Lilly MG HR and SS are employees of and have stock ownership in Amgen Inc

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Other Papers In This Journal:
  1. Development of an electronic medical record based intervention to improve medical care of osteoporosis
  2. Morbidity following lower extremity fractures in men with spinal cord injury
  3. DXA-based hip structural analysis of once-weekly bisphosphonate-treated postmenopausal women with low bone mass
  4. Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women
  5. Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures
  6. Evaluation of three risk assessment tools in discriminating fracture status among Chinese patients undergoing hemodialysis
  7. Oral bisphosphonates and risk of ischemic stroke: a case–control study
  8. The association between serum osteocalcin levels and metabolic syndrome in Koreans
  9. Place of residence and risk of fracture in older people: a population-based study of over 65-year-olds in Cardiff
  10. Fracture risk and adjuvant hormonal therapy among a population-based cohort of older female breast cancer patients
  11. Cost-utility of long-term strontium ranelate treatment for postmenopausal osteoporotic women
  12. Effects of therapeutic exercise for persons with osteoporotic vertebral fractures: a systematic review
  13. Genetic analysis of serum osteocalcin and bone mineral in multigenerational Afro-Caribbean families
  14. Effect of hospitalist consultation on treatment of osteoporosis in hip fracture patients
  15. Declining incidence of low-trauma knee fractures in elderly women: nationwide statistics in Finland between 1970 and 2006
  16. Changing health behaviors with social marketing
  17. Selective protein depletion impairs bone growth and causes liver fatty infiltration in female rats: prevention by Spirulina alga
  18. The vertebral fracture cascade in osteoporosis: a review of aetiopathogenesis
  19. Clinical performance of osteoporosis risk assessment tools in women aged 67 years and older
  20. Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database
  21. One year outcomes and costs following a vertebral fracture
  22. Use of proton pump inhibitors is associated with fractures in young adults: a population-based study
  23. Classification of women with and without hip fracture based on quantitative computed tomography and finite element analysis
  24. Influence of age and sex steroids on bone density and geometry in middle-aged and elderly European men
  25. The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women
  26. Effects of a combined alendronate and calcitriol agent (Maxmarvil®) on bone metabolism in Korean postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study
  27. Tracking of size-adjusted bone mineral content and bone area in boys and girls from 10 to 17 years of age
  28. Vertebral Scheuermann’s disease in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over
  29. Age-related hyperkyphosis, independent of spinal osteoporosis, is associated with impaired mobility in older community-dwelling women
  30. Performance of COLIA1 Polymorphism and Bone Turnover Markers to Identify Postmenopausal Women with Prevalent Vertebral Fractures
  31. Economic burden of privately insured non-vertebral fracture patients with osteoporosis over a 2-year period in the US
  32. Vitamin D status in men with psoriatic arthritis: a case-control study
  33. Long-term treatment of osteoporotic women with bisphosphonates does not impair the response to subsequently administered intravenous pamidronate
  34. Treatment satisfaction and persistence among postmenopausal women on osteoporosis medications: 12-month results from POSSIBLE US™
  35. Combining clinical factors and quantitative ultrasound improves the detection of women both at low and high risk for hip fracture
  36. De novo autoimmune hepatitis associated with PTH(1–34) and PTH(1–84) administration for severe osteoporosis in a liver transplant patient
  37. Basic fibroblast growth factor has rapid bone anabolic effects in ovariectomized rats
  38. Precision of 18 F-fluoride PET skeletal kinetic studies in the assessment of bone metabolism
  39. RETRACTED ARTICLE: Nitrate use and changes in bone mineral density: the Canadian Multicentre Osteoporosis Study
  40. Clinical characteristics and risk factors of postoperative pneumonia after hip fracture surgery: a prospective cohort study
  41. Quantitative ultrasound and fracture risk prediction in non-osteoporotic men and women as defined by WHO criteria
  42. Treatment with acetaminophen/paracetamol or ibuprofen alleviates post-dose symptoms related to intravenous infusion with zoledronic acid 5 mg
  43. Serum sclerostin: the missing link in the bone-vessel cross-talk in hemodialysis patients?
  44. Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw: reply to Subramanian and Quek
  45. The Presence and Severity of Vertebral Fractures is Associated with the Presence of Esophageal Hiatal Hernia in Postmenopausal Women
  46. Intervention thresholds for osteoporosis in men and women: a study based on data from Sweden
  47. Influence of fall related factors and bone strength on fracture risk in the frail elderly
  48. Discriminative value of FRAX for fracture prediction in a cohort of Chinese postmenopausal women
  49. Effects of alendronate and vitamin D in patients with normocalcemic primary hyperparathyroidism
  50. Stroke in relation to use of raloxifene and other drugs against osteoporosis
  51. Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women
  52. The relationship between low bone mass and metabolic syndrome in Korean women
  53. Effect of high-dose cholecalciferol (vitamin D 3 ) on bone and body composition in children and young adults with HIV infection: a randomized, double-blind, placebo-controlled trial
  54. Initiation of anti-osteoporotic therapy in patients with recent fractures: a nationwide analysis of prescription rates and persistence
  55. Treatment of osteoporosis after alendronate or risedronate
  56. Vertebral anti-fracture efficacy of strontium ranelate according to pre-treatment bone turnover
  57. Estrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women
  58. Bone mass following physical activity in young years: a mean 39-year prospective controlled study in men
  59. Fracture Reduction Affects Medicare Economics (FRAME): Impact of increased osteoporosis diagnosis and treatment
  60. Low skeletal muscle mass associates with low femoral neck strength, especially in older Korean women: the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)
  61. Age-related differences in the activity of arterial mineral deposition and regional bone metabolism: a 18 F-sodium fluoride positron emission tomography study
  62. Copper deficit as a potential pathogenic factor of reduced bone mineral density and severe tooth wear
  63. Has Choosing Wisely® affected rates of dual-energy X-ray absorptiometry use?
  64. RisedronatE and ALendronate Intervention over Three Years (REALITY): minimal differences in fracture risk reduction
  65. Sensitivity and specificity of radiographic characteristics in atypical femoral fractures
  66. The interaction of ethnicity and chronic disease as risk factors for osteoporotic fractures: a comparison in Canadian Aboriginals and non-Aboriginals
  67. Association between osteocalcin and glucose metabolism: a meta-analysis
  68. Decreased serum sclerostin levels in patients with primary hyperparathyroidism: a cross-sectional and a longitudinal study
  69. Targeted education improves the very low recognition of vertebral fractures and osteoporosis management by general internists
  70. Evaluation of panoramic radiomorphometric indices related to low bone density in sickle cell disease
  71. Morphological changes of injected calcium phosphate cement in osteoporotic compressed vertebral bodies
  72. Both resistance and agility training reduce back pain and improve health-related quality of life in older women with low bone mass
  73. Homocysteine and fracture risk in postmenopausal women: the OFELY study
  74. Excess mortality following hip fracture: a systematic epidemiological review
  75. A double-blind, randomized, Phase III, multicenter study in 358 pediatric subjects receiving isotretinoin therapy demonstrates no effect on pediatric bone mineral density
  76. Development and application of a Japanese model of the WHO fracture risk assessment tool (FRAX™)
  77. Weight loss and distal forearm fractures in postmenopausal women
  78. Implementation of osteoporosis guidelines: a survey of five large fracture liaison services in the Netherlands
  79. Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats
  80. Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats
  81. BsmI vitamin D receptor genotypes influence the efficacy of antiresorptive treatments in postmenopausal osteoporotic women. A 1-year multicenter, randomized and controlled trial
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