Authors: Y Albeyatti M Siddique M L Frost I Fogelman G M Blake
Publish Date: 2012/01/12
Volume: 23, Issue: 10, Pages: 2535-2541
Abstract
We assessed the precision of lumbar spine 18FPET measurements based on 58 scans performed on 20 postmenopausal women The percentage coefficient of variation CV 95 confidence interval was 92 75–118 for standardised uptake values 117 95–149 for plasma clearance measurements using the Patlak method and 145 117–185 for plasma clearance measurements using the Hawkins threecompartment model18FFluoride positron emission tomography 18FPET is a noninvasive technique that allows the assessment of regional bone turnover in patients with metabolic bone disease Knowledge of the precision errors of 18FPET measurements is important for planning the number of subjects required for research studiesTwenty osteoporotic postmenopausal women had 18FPET scans of the lumbar spine at 0 6 and 12 months after stopping longterm bisphosphonate treatment No significant changes in the PET measurements were seen over the 12month period and the data were deemed suitable for a precision study Precision errors were evaluated for standardised uptake values SUVs and for the fluoride plasma clearance to bone mineral K i determined using the Patlak and Hawkins methods Precision errors were expressed as the CV and were calculated for the mean L1–L4 region and for individual vertebraeCV 95 confidence interval for the L1–L4 region was 92 75–118 for SUV 117 95–149 for K i measured using the Patlak method and 145 117–185 for K i measured using the Hawkins method There was no significant difference between precision errors obtained for the L1–L4 region and those obtained for a single vertebraSUV measurements showed the smallest precision error followed by the Patlak method while the Hawkins method gave the largest error Measuring a smaller region of interest did not increase the precision error suggesting that the factor determining the errors may be scanner calibration
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