Authors: MS M Ardawi A M AlSibiany T M Bakhsh A A Rouzi M H Qari
Publish Date: 2011/10/28
Volume: 23, Issue: 6, Pages: 1789-1797
Abstract
There is limited information on the changes of serum sclerostin in conditions with chronic PTH excess in humans The main objectives of the present study were to 1 examine crosssectionally the changes of serum sclerostin levels in patients with primary hyperparathyroidism PHPT 2 study the time course changes in serum sclerostin in PHPT patients following parathyroidectomy PTX followed up longitudinally for 12 months and 3 compare the changes in serum sclerostin to that of BTMsWe studied 60 PHPT patients and compared them with 74 PTX patients together with 268 age and sexmatched healthy controls Also we followed 27 PTX patients longitudinally at 2 4 6 10 30 60 180 and 360 days postoperatively Serum sclerostin BTMs and minerals were measured Also bone mineral density was determined by dual energy Xray absorptiometryPatients with PHPT exhibited significantly lower mean serum sclerostin mean in picomoles per liter 95 confidence interval CI 2898 2794–3003 than that obtained for PTX patients 3701 3575–3827 and healthy controls 4622 4513–4731 P 00001 for each case respectively Serum PTH inversely correlated with serum sclerostin r = −0651 P 00001 Serum sclerostin was normalized in PTX patients by the tenth day postoperatively and remained within the expected reference range thereafterSignificantly decreased serum sclerostin was evidenced in PHPT patients as compared with PTX and euparathyroid controls The inverse PTH and sclerostin relationship suggests that sclerostin is downregulated by PTH in humans Serum sclerostin normalized earlier than BTMs following parathyroidectomyWe are grateful to the Ministry of Higher Education for financial support to the Center of Excellence for Osteoporosis Research CEOR at King Abdulaziz University grant s CEOR/00108 and CEOR/00408 Jeddah Saudi Arabia We thank Dr M Bellal and Dr AA Yousif at the Department of Surgery of the New Jeddah Clinic Hospital for their help in the longitudinal study of the present work We thank all the subjects who participated in the present study and we thank all the staff and colleagues at CEOR King Abdulaziz University Hospital New Jeddah Clinic Hospital AlKhandara Clinic Hospital and the Primary Care Health Centers for their invaluable assistance during the execution of the present study Special thanks are due to Ms Veronica Orbacedo for her excellent secretarial help
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