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Title of Journal: Osteoporos Int

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Abbravation: Osteoporosis International

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Springer-Verlag

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ISSN

1433-2965

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The interaction of ethnicity and chronic disease a

Authors: W D Leslie S Derksen H J Prior L M Lix C Metge J O’Neil
Publish Date: 2006/06/13
Volume: 17, Issue: 9, Pages: 1358-1368
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Abstract

Efforts to develop global methods for absolute fracture risk prediction are currently limited by uncertainty over the validity of these models in nonWhite populations Aboriginal Canadians have higher fractures rates than nonAboriginals This analysis examined the interaction of ethnicity with diabetes mellitus disease comorbidity and substance abuse as possible explanatory variablesA retrospective populationbased matched cohort study of fracture rates was performed using Manitoba administrative health data 1984–2003 The study cohort consisted of 27952 registered Aboriginal adults aged 20 years or older and 83856 nonAboriginal controls matched three to one for year of birth and gender Diabetes mellitus number of ambulatory disease groups ADGs substance abuse and incident fractures were based upon validated definitions Poisson regression analyses of fracture rates modelled the explanatory variables as main effects and twoway interactions with ethnicityOsteoporotic fracture rates were approximately twofold higher in the Aboriginal cohort p00001 Diabetes greater number of ADGs and substance abuse were all more common in the Aboriginal cohort all p00001 These factors were associated with increased fracture rates all p00001 and significantly higher population attributable risk percent in the Aboriginal cohort all p00001 However no significant interactions between the risk factors and ethnicity were observed p01 for all interaction effectsGreater prevalence of diabetes comorbidity and substance abuse contributes to higher rates of fracture The relative risk of fracture for these factors is similar for both Aboriginal and nonAboriginals despite large differences in absolute fracture risk and risk factor prevalenceSupported by a research grant from the Canadian Institutes for Health Research The authors are indebted to Manitoba Health for providing the data used in this study to the First Nations and Inuit Health Branch and Indian and Northern Affairs Canada for permission to use the Status Verification System and to the Health Information Research Committee of the Assembly of Manitoba Chiefs for actively supporting this work The results and conclusions are those of the authors and no official endorsement by Manitoba Health or the Assembly of Manitoba Chiefs is intended or should be inferred


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  2. Morbidity following lower extremity fractures in men with spinal cord injury
  3. DXA-based hip structural analysis of once-weekly bisphosphonate-treated postmenopausal women with low bone mass
  4. Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women
  5. Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures
  6. Evaluation of three risk assessment tools in discriminating fracture status among Chinese patients undergoing hemodialysis
  7. Oral bisphosphonates and risk of ischemic stroke: a case–control study
  8. The association between serum osteocalcin levels and metabolic syndrome in Koreans
  9. Place of residence and risk of fracture in older people: a population-based study of over 65-year-olds in Cardiff
  10. Fracture risk and adjuvant hormonal therapy among a population-based cohort of older female breast cancer patients
  11. Cost-utility of long-term strontium ranelate treatment for postmenopausal osteoporotic women
  12. Effects of therapeutic exercise for persons with osteoporotic vertebral fractures: a systematic review
  13. Genetic analysis of serum osteocalcin and bone mineral in multigenerational Afro-Caribbean families
  14. Effect of hospitalist consultation on treatment of osteoporosis in hip fracture patients
  15. Declining incidence of low-trauma knee fractures in elderly women: nationwide statistics in Finland between 1970 and 2006
  16. Changing health behaviors with social marketing
  17. Selective protein depletion impairs bone growth and causes liver fatty infiltration in female rats: prevention by Spirulina alga
  18. The vertebral fracture cascade in osteoporosis: a review of aetiopathogenesis
  19. Clinical performance of osteoporosis risk assessment tools in women aged 67 years and older
  20. Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database
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  25. The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women
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