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Title of Journal: Osteoporos Int

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Abbravation: Osteoporosis International

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Springer London

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DOI

10.1007/s10597-005-2599-z

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ISSN

1433-2965

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RETRACTED ARTICLE Nitrate use and changes in bone

Authors: S A Jamal D Goltzman D A Hanley A Papaioannou J C Prior R G Josse
Publish Date: 2008/09/18
Volume: 20, Issue: 5, Pages: 737-744
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Abstract

Nitrates may have beneficial effects on bone To determine if nitrates were associated with increased bone mineral density BMD we conducted a secondary analysis using data from subjects in a prospective study Subjects reporting nitrate use had increased BMD compared with nonusers confirming that nitrates have positive BMD effects in women and menWe used linear regression models stratified by gender and adjusted for age weight and baseline differences to determine the association between daily nitrate use and BMD among subjects participating in the Canadian Multicentre Osteoporosis Study All results are reported as annualised percent change in BMD at the hip and spine among nitrate users compared to nonusersWe included 1419 men 71 reported daily nitrate use and 2587 women 97 reported daily nitrate use Male nonusers had decreased hip BMD −13 95 confidence interval 95CI = −16 to −11 and increased spine BMD 28 95CI = 25 to 31 Male nitrate users had increased hip BMD 14 95CI = 01 to 28 and spine BMD 45 95CI = 32 to 57 Among women nonusers had decreased hip BMD −19 95CI = −21 to −17 and increased spine BMD 21 95CI = 19 to 24 whilst users had an increase in hip BMD 20 95CI = 12 to 28 and spine BMD 41 95CI = 34 to 49The majority of the authors of this work believe the original conclusions presented have been compromised by inconsistencies in the data and the article should be retracted a decision supported by the Editors of Osteoporosis International The following authors agree with this retraction decision David Goltzman David A Hanley Alexandra Papaioannou Jerilynn C Prior Robert G Josse The following author could not be reached for comment Sophie A Jamal The authors deeply regret the impact of this action on the work of other investigatorsThis study was supported by the Canadian Institutes of Health Research Merck Frosst Canada Eli Lilly Canada Novartis Pharmaceuticals The Alliance for Better Bone Health SanofiAventis and Procter and Gamble Pharmaceuticals Canada The Dairy Farmers of Canada and The Arthritis Society


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  2. Morbidity following lower extremity fractures in men with spinal cord injury
  3. DXA-based hip structural analysis of once-weekly bisphosphonate-treated postmenopausal women with low bone mass
  4. Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women
  5. Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures
  6. Evaluation of three risk assessment tools in discriminating fracture status among Chinese patients undergoing hemodialysis
  7. Oral bisphosphonates and risk of ischemic stroke: a case–control study
  8. The association between serum osteocalcin levels and metabolic syndrome in Koreans
  9. Place of residence and risk of fracture in older people: a population-based study of over 65-year-olds in Cardiff
  10. Fracture risk and adjuvant hormonal therapy among a population-based cohort of older female breast cancer patients
  11. Cost-utility of long-term strontium ranelate treatment for postmenopausal osteoporotic women
  12. Effects of therapeutic exercise for persons with osteoporotic vertebral fractures: a systematic review
  13. Genetic analysis of serum osteocalcin and bone mineral in multigenerational Afro-Caribbean families
  14. Effect of hospitalist consultation on treatment of osteoporosis in hip fracture patients
  15. Declining incidence of low-trauma knee fractures in elderly women: nationwide statistics in Finland between 1970 and 2006
  16. Changing health behaviors with social marketing
  17. Selective protein depletion impairs bone growth and causes liver fatty infiltration in female rats: prevention by Spirulina alga
  18. The vertebral fracture cascade in osteoporosis: a review of aetiopathogenesis
  19. Clinical performance of osteoporosis risk assessment tools in women aged 67 years and older
  20. Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database
  21. One year outcomes and costs following a vertebral fracture
  22. Use of proton pump inhibitors is associated with fractures in young adults: a population-based study
  23. Classification of women with and without hip fracture based on quantitative computed tomography and finite element analysis
  24. Influence of age and sex steroids on bone density and geometry in middle-aged and elderly European men
  25. The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women
  26. Effects of a combined alendronate and calcitriol agent (Maxmarvil®) on bone metabolism in Korean postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study
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  31. Economic burden of privately insured non-vertebral fracture patients with osteoporosis over a 2-year period in the US
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  34. Treatment satisfaction and persistence among postmenopausal women on osteoporosis medications: 12-month results from POSSIBLE US™
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  40. Quantitative ultrasound and fracture risk prediction in non-osteoporotic men and women as defined by WHO criteria
  41. Treatment with acetaminophen/paracetamol or ibuprofen alleviates post-dose symptoms related to intravenous infusion with zoledronic acid 5 mg
  42. Serum sclerostin: the missing link in the bone-vessel cross-talk in hemodialysis patients?
  43. Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw: reply to Subramanian and Quek
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  49. Stroke in relation to use of raloxifene and other drugs against osteoporosis
  50. Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women
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  54. Treatment of osteoporosis after alendronate or risedronate
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  58. Fracture Reduction Affects Medicare Economics (FRAME): Impact of increased osteoporosis diagnosis and treatment
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  66. Association between osteocalcin and glucose metabolism: a meta-analysis
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