Authors: C Fournier R Rizzoli K Bouzakri P Ammann
Publish Date: 2016/06/25
Volume: 27, Issue: 11, Pages: 3365-3376
Abstract
Chronic protein malnutrition leads to child mortality in developing countries Spirulina alga SPI being rich in protein and growing easily is a good candidate as supplementation We showed that SPI completely prevents bone growth retardation and liver disturbances observed in young rats fed a low protein diet This supports SPI as a useful source of vegetable protein to fight against protein malnutritionChronic malnutrition is a main factor of child mortality in developing countries A low protein diet impairs wholebody growth and leads to fatty liver in growing rats SPI has great potential as a supplementation as it has a 60 protein content and all essential amino acids However its specific impact on bone growth and the related secretion of hepatokines have not yet been studiedTo address this question 6weekold female rats were fed isocaloric diets containing 10 casein 5 casein or 5 casein + 5 protein from SPI during 9 weeks Changes in tibia geometry microarchitecture BMC BMD and biomechanical properties were analyzed Serum IGFI FGF21 follistatin and activin A were assessed as well as their hepatic gene expressions in addition to those of Sirt1 Ghr and Igf1r Hepatic fat content was also assessedA low protein diet altered bone geometry and reduced proximal tibia BMD and trabecular bone volume In addition it increased hepatic fat content and led to hepatic GH resistance by decreasing serum IGFI and increasing serum FGF21 without altering serum activin A and follistatin SPI prevented low protein dietinduced bone hepatic and hormonal changes and even led to higher biomechanical properties and lower hepatic fat content in association with specific InhbA and Follistatin expression changes vs the 10 casein group
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