Authors: Aj Chang Q Ying Xn Chen Wm Wang N Chen
Publish Date: 2016/07/08
Volume: 27, Issue: 12, Pages: 3599-3606
Abstract
We evaluated three risk assessment tools including bone mineral density BMD measurement by dual energy Xray absorptiometry DXA osteoporosis selfassessment tool for Asians OSTA and fracture risk assessment tool FRAX for the prediction of fracture status among Chinese patients undergoing hemodialysis All of the three assessment tools have a reasonable capability in discriminating fracturesFractures are common in hemodialysis patients however insufficiently assessed Our study aimed to assess the ability of three widely used tools BMD OSTA and FRAX to discriminate fracture status in patients with renal failure undergoing hemodialysisWe enrolled 136 hemodialysis patients in a tertiary teaching hospital setting BMD was measured using DXA at the lumbar spine and the hip region OSTA was calculated from weight and age FRAX score was calculated based upon online availability Discriminative abilities of BMD OSTA and FRAX in fracture status were analyzed by receiver operator characteristic ROC curvesThere were total 16 fractures 1176 identified in 136 hemodialysis patients BMD at any site lumbar spine L1L4 femoral neck and total hip was independently associated with fracture Areas under the curves AUC of BMD lumbar spine L1L4 femoral neck total hip OSTA FRAX1 nonBMD model and FRAX2 BMD model were 0669 95 CI 0583 0747 0708 95 CI 0624 0783 0736 95 CI 0654 0808 0686 95 CI 0601 0763 0715 95 CI 0631 0789 and 0697 95 CI 0613 0773 respectively The differences of their performance were not significantAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards
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