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Title of Journal: Osteoporos Int

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Abbravation: Osteoporosis International

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Springer-Verlag

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DOI

10.1007/bf02333122

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ISSN

1433-2965

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Genetic analysis of serum osteocalcin and bone min

Authors: A L Kuipers C Gundberg C M Kammerer A S Dressen C S Nestlerode A L Patrick V W Wheeler C H Bunker A B Newman J M Zmuda
Publish Date: 2011/09/21
Volume: 23, Issue: 5, Pages: 1521-1531
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Abstract

Osteocalcin OC is a protein constituent of bone matrix and a marker of bone formation We characterized the heritability of serum OC measures and identified genomic regions potentially involved in the regulation of OC via highdensity genomewide linkage analysis in African ancestry individualsAfrican ancestry individuals n = 459 were recruited without regard to health status from seven probands mean family size = 66 4373 relative pairs Residual heritability of serum OC measures was estimated and multipoint quantitative trait linkage analysis was performed using pedigreebased maximum likelihood methodsResidual heritabilities of total OC uncarboxylated OC carboxylated OC and percent uncarboxylated OC were 074 ± 010 089 ± 008 046 ± 010 and 041 ± 009 respectively All OC measures were genetically correlated with whole body BMC We obtained strong evidence of bivariate linkage for percent uncarboxylated OC and whole body BMC on chromosome 17 logarithm of the odds LOD = 315 99 cMAll forms of OC were highly heritable and genetically correlated with total body BMC in these African ancestry families The identified linkage region contains several candidate genes for bone and energy metabolism including COL1A1 and TNFRSF11A Further studies of this genomic region may reveal novel insight into the genetic regulation of OC and bone mineralization

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