Authors: S J Bae J W Choe YE Chung BJ Kim S H Lee H Y Kim JM Koh H K Kim G S Kim
Publish Date: 2010/12/09
Volume: 22, Issue: 11, Pages: 2837-2846
Abstract
The association between serum osteocalcin levels and metabolic syndrome MS in Korean individuals was investigated Serum osteocalcin levels are significantly lower in subjects with MS than in those without the disease regardless of glucose metabolismSerum osteocalcin concentrations were significantly lower in subjects with MS than those without MS in postmenopausal women 18923 ± 7685 vs 22513 ± 7344 ng/ml P 0001 and marginally lower in subjects with MS than those without MS in men 14550 ± 5090 vs 16125 ± 4749 ng/ml P = 0086 after adjustment for age and BMI Further controlling with CTX or ALP did not affect this association in postmenopausal women however controlling with osteocalcin abolished the association between CTX and MS Significant differences in serum osteocalcin levels by MS status were noted in subjects with normal glucose tolerance as well as those with abnormal glucose tolerance P = 0032 and P 0001 respectively Compared with subjects with the highest quartile of osteocalcin those in the lower quartile groups Q1–Q3 had significantly increased risks of MS ORs = 518 CIs = 115–2342 in men In postmenopausal women the ORs for MS were significantly higher in the lowest quartile than in the highest quartile ORs = 525 CIs = 242–1136
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