Authors: S Bharadwaj A G T Naidu G V Betageri N V Prasadarao A S Naidu
Publish Date: 2009/01/27
Volume: 20, Issue: 9, Pages: 1603-1611
Abstract
Current treatments for postmenopausal osteoporosis suffer from side effects Safe and natural milk proteins ribonuclease and lactoferrin promote formation of new capillaries and bone formation A ribonucleaseenriched lactoferrin supplement studied here demonstrates significant reduction in resorption and increase in formation towards restoring the balance of bone turnover within 6 monthsOsteoporosis a major health issue among postmenopausal women causes increased bone resorption and reduced bone formation A reduction in angiogenesis could also contribute to this imbalance Current treatments such as hormone replacement therapy and bisphosphonates have drawbacks of severe side effects Milk ribonuclease RNase is known to promote angiogenesis and lactoferrin LF to stimulate bone formation by osteoblasts We examine the effect of ribonucleaseenriched lactoferrin supplement on the bone health of postmenopausal womenA total of 38 healthy postmenopausal women aged 45 to 60 years were randomized into placebo or RNAseenrichedLF RELF supplement groups The bone health status was monitored by assessing bone resorption markers serum Ntelopeptides NTx and urine deoxypyridinoline Dpd crosslinks and serum bone formation markers bonespecific alkaline phosphatase BAP and osteocalcin OCRELF supplementation demonstrated a decrease in urine Dpd levels by 14 19 increase for placebo and serum NTx maintained at 24 of the baseline 41 for placebo while serum BAP and OC levels showed a 45 and 16 elevation 25 and 5 for placebo
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