Authors: P Anagnostis Z A Efstathiadou E Akriviadis P Hytiroglou M Kita
Publish Date: 2011/11/26
Volume: 23, Issue: 9, Pages: 2387-2391
Abstract
De novo autoimmune hepatitis AIH is a rare graft dysfunction occurring in patients having undergone liver transplantation LT for causes other than AIH We describe for the first time a case of de novo AIH associated with the administration of parathyroid hormone 1–34 PTH1–34 and PTH1–84 for severe osteoporosis A 61yearold woman was referred to our metabolic bone clinic due to severe osteoporosis 3 years after LT for primary biliary cirrhosis Initial treatment with PTH1–34 led to asymptomatic hypertransaminasemia twofold the upper limit of normal which normalized after drug discontinuation A new flare of transaminases threefold the upper limit of normal along with elevated alkaline phosphatase was observed after administration of PTH1–84 which did not resolve after PTH1–84 withdrawal Subsequently after exclusion of common causes of liver enzyme elevation a liver biopsy was performed Histological findings showed de novo AIH which responded rapidly to treatment with methylprednisolone
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