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Title of Journal: Osteoporos Int

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Abbravation: Osteoporosis International

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Publisher

Springer London

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DOI

10.1006/jcph.2001.6871

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ISSN

1433-2965

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Agerelated differences in the activity of arteria

Authors: T Derlin T Janssen J Salamon S Veldhoen J D Busch G Schön J Herrmann F O Henes P Bannas G Adam
Publish Date: 2014/08/16
Volume: 26, Issue: 1, Pages: 199-207
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Abstract

The extent of arterial calcification increases with age whereas bone mineral density decreases evidencing a wellknown inverse correlation on morphological basis The aim of this study was to evaluate the functional relationship between the activity of arterial mineral deposition and regional bone metabolism as assessed by 18Fsodium fluoride NaF PET/CTThree hundred four subjects were examined by 18FNaF PET/CT Tracer accumulation in the femoral arteries was analyzed both qualitatively and semiquantitatively by measuring the bloodpoolcorrected standardized uptake value targettobackground ratio Uptake was compared with cardiovascular risk factors RFs calcified plaque burden and regional bone metabolism as assessed by PET/CTThe activity of arterial mineral deposition significantly increased with age p  0001 whereas regional bone metabolism significantly decreased p  0001 There was a significant inverse correlation between bone metabolism and arterial mineral deposition unadjusted p  0001 that association was not significant p = 079 when controlled for age and other RFs Both high activity of arterial mineral deposition and low bone metabolism were significantly associated with cardiovascular events and other RFs18FNaF PET/CT provides a tool to visualize and quantify the activity of arterial mineral deposition and regional bone metabolism In this study we observed an inverse correlation between the activity of arterial mineral deposition and regional bone metabolism While the activity of arterial mineral deposition significantly increases with age regional bone metabolism decreases

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