Authors: DM Liu XZ Guo HJ Tong B Tao LH Sun HY Zhao G Ning JM Liu
Publish Date: 2015/06/19
Volume: 26, Issue: 12, Pages: 2823-2833
Abstract
This metaanalysis aimed to investigate the associations between osteocalcin Ocn and fasting plasma glucose FPG and glycated hemoglobin A1c HbA1c It was revealed that both total Ocn and undercarboxylated Ocn unOcn were negatively related with FPG and HbA1c and the association of unOcn with FPG was more pronounced in menThe metaanalysis included 39 studies involving 23381 participants The overall correlation was −016 95 CI −019 to −014 between total Ocn tOcn and FPG and −015 95 CI −020 to −011 between undercarboxylated Ocn unOcn and FPG In the analysis of the association between Ocn and HbA1c the pooled correlation was −016 95 CI −018 to −014 for tOcn and −016 95 CI −023 to −008 for unOcn The magnitude of the correlation between unOcn and FPG is significantly higher in men than in women r = −018 95 CI −021 to −014 r = −009 95 CI −0 13 to −005 respectively P for interaction 005 Similar trend was also found between unOcn and HbA1c but without significance for men r = −019 95 CI −024 to −014 for women r = −009 95 CI −022 to 004 respectively P for interaction 005 No indication of significant publication bias was found in any method
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