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Title of Journal: Osteoporos Int

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Abbravation: Osteoporosis International

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Springer London

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DOI

10.1002/chin.200814230

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ISSN

1433-2965

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Effect of highdose cholecalciferol vitamin DSub

Authors: A J Rovner V A Stallings R Rutstein J I Schall M B Leonard B S Zemel
Publish Date: 2016/11/11
Volume: 28, Issue: 1, Pages: 201-209
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Abstract

It is unknown whether vitamin D supplementation positively impacts body composition and bone outcomes in children and young adults with HIV This RCT found that despite increasing 25OHD concentrations high dose vitamin D3 supplementation did not impact bone or body composition in children and young adults with HIV infectionThe objective of this paper was to determine the impact of highdose daily cholecalciferol vitamin D3 supplementation on body composition and bone density structure and strength in children and young adults with perinatally acquired PHIV or behaviorally acquired BHIV HIV infectionParticipants were randomized to receive vitamin D3 supplementation 7000 IU/day or placebo for 12 months Serum 25hydroxyvitamin D 25OHD concentrations dual energy Xray absorptiometry DXA of the whole body and lumbar spine and peripheral quantitative computed tomography pQCT of tibia sites were acquired at 0 6 and 12 months DXA and pQCT outcomes were expressed as sex and populationancestry specific Zscores relative to age and adjusted for height or tibia length as appropriateFiftyeight participants 50 to 249 years received vitamin D3 supplements n = 30 or placebo n = 28 At enrollment groups were similar in age sex population ancestry growth status serum 25OHD concentrations body composition and sizeadjusted bone measures Median 25OHD concentrations were similar 173 ng/mL in the vitamin D3 supplementation group vs 156 ng/mL in the placebo group and both groups had mild bone deficits At 12 months 25OHD rose significantly in the vitamin D supplementation group but not in the placebo group 264 vs 148 ng/mL respectively p  0008 After adjusting for population ancestry sex antiretroviral therapy use and season there were no significant treatment group differences in bone or body composition outcomesWe are grateful to the study participants and their families We would like to thank Julia L Samuel and Savannah Knell as the lead study staff members In addition we would like to acknowledge the Clinical Translational Research Center the Special Immunology Family Care Clinic Adolescent Initiative Program at CHOP Jonathan Lax Treatment Center Cooper University Hospital Alfred I duPont Hospital for Children Hospital of the University of Pennsylvania Temple University Hospital and Drexel University HospitalThis work was supported by the NIH/National Center for Complementary and Alternative Medicine Grant R01AT005531 the National Center for Research Resources Grant UL1RR024134 and is now at the National Center for Advancing Translational Sciences Grant UL1TR000003 The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH This publication was made possible through core services and support from the University of Pennsylvania Center for AIDS Research an NIHfunded program P30AI045008 Additional support was from the Jean A Cortner Endowed Chair Nutrition Center and the Research Institute at the Children’s Hospital of Philadelphia Life Extension Ft Lauderdale FL and JR Carlson Laboratories Inc Arlington Heights IL donated the vitamin D3 supplements and placebo capsules and drops respectively


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  2. Morbidity following lower extremity fractures in men with spinal cord injury
  3. DXA-based hip structural analysis of once-weekly bisphosphonate-treated postmenopausal women with low bone mass
  4. Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women
  5. Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures
  6. Evaluation of three risk assessment tools in discriminating fracture status among Chinese patients undergoing hemodialysis
  7. Oral bisphosphonates and risk of ischemic stroke: a case–control study
  8. The association between serum osteocalcin levels and metabolic syndrome in Koreans
  9. Place of residence and risk of fracture in older people: a population-based study of over 65-year-olds in Cardiff
  10. Fracture risk and adjuvant hormonal therapy among a population-based cohort of older female breast cancer patients
  11. Cost-utility of long-term strontium ranelate treatment for postmenopausal osteoporotic women
  12. Effects of therapeutic exercise for persons with osteoporotic vertebral fractures: a systematic review
  13. Genetic analysis of serum osteocalcin and bone mineral in multigenerational Afro-Caribbean families
  14. Effect of hospitalist consultation on treatment of osteoporosis in hip fracture patients
  15. Declining incidence of low-trauma knee fractures in elderly women: nationwide statistics in Finland between 1970 and 2006
  16. Changing health behaviors with social marketing
  17. Selective protein depletion impairs bone growth and causes liver fatty infiltration in female rats: prevention by Spirulina alga
  18. The vertebral fracture cascade in osteoporosis: a review of aetiopathogenesis
  19. Clinical performance of osteoporosis risk assessment tools in women aged 67 years and older
  20. Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database
  21. One year outcomes and costs following a vertebral fracture
  22. Use of proton pump inhibitors is associated with fractures in young adults: a population-based study
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  25. The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women
  26. Effects of a combined alendronate and calcitriol agent (Maxmarvil®) on bone metabolism in Korean postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study
  27. Tracking of size-adjusted bone mineral content and bone area in boys and girls from 10 to 17 years of age
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  30. Performance of COLIA1 Polymorphism and Bone Turnover Markers to Identify Postmenopausal Women with Prevalent Vertebral Fractures
  31. Economic burden of privately insured non-vertebral fracture patients with osteoporosis over a 2-year period in the US
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  33. Long-term treatment of osteoporotic women with bisphosphonates does not impair the response to subsequently administered intravenous pamidronate
  34. Treatment satisfaction and persistence among postmenopausal women on osteoporosis medications: 12-month results from POSSIBLE US™
  35. Combining clinical factors and quantitative ultrasound improves the detection of women both at low and high risk for hip fracture
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  40. Clinical characteristics and risk factors of postoperative pneumonia after hip fracture surgery: a prospective cohort study
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  42. Treatment with acetaminophen/paracetamol or ibuprofen alleviates post-dose symptoms related to intravenous infusion with zoledronic acid 5 mg
  43. Serum sclerostin: the missing link in the bone-vessel cross-talk in hemodialysis patients?
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  47. Influence of fall related factors and bone strength on fracture risk in the frail elderly
  48. Discriminative value of FRAX for fracture prediction in a cohort of Chinese postmenopausal women
  49. Effects of alendronate and vitamin D in patients with normocalcemic primary hyperparathyroidism
  50. Stroke in relation to use of raloxifene and other drugs against osteoporosis
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  52. The relationship between low bone mass and metabolic syndrome in Korean women
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  54. Treatment of osteoporosis after alendronate or risedronate
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  56. Estrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women
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  58. Fracture Reduction Affects Medicare Economics (FRAME): Impact of increased osteoporosis diagnosis and treatment
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  64. Sensitivity and specificity of radiographic characteristics in atypical femoral fractures
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  66. Association between osteocalcin and glucose metabolism: a meta-analysis
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  73. Homocysteine and fracture risk in postmenopausal women: the OFELY study
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