Authors: A J Rovner V A Stallings R Rutstein J I Schall M B Leonard B S Zemel
Publish Date: 2016/11/11
Volume: 28, Issue: 1, Pages: 201-209
Abstract
It is unknown whether vitamin D supplementation positively impacts body composition and bone outcomes in children and young adults with HIV This RCT found that despite increasing 25OHD concentrations high dose vitamin D3 supplementation did not impact bone or body composition in children and young adults with HIV infectionThe objective of this paper was to determine the impact of highdose daily cholecalciferol vitamin D3 supplementation on body composition and bone density structure and strength in children and young adults with perinatally acquired PHIV or behaviorally acquired BHIV HIV infectionParticipants were randomized to receive vitamin D3 supplementation 7000 IU/day or placebo for 12 months Serum 25hydroxyvitamin D 25OHD concentrations dual energy Xray absorptiometry DXA of the whole body and lumbar spine and peripheral quantitative computed tomography pQCT of tibia sites were acquired at 0 6 and 12 months DXA and pQCT outcomes were expressed as sex and populationancestry specific Zscores relative to age and adjusted for height or tibia length as appropriateFiftyeight participants 50 to 249 years received vitamin D3 supplements n = 30 or placebo n = 28 At enrollment groups were similar in age sex population ancestry growth status serum 25OHD concentrations body composition and sizeadjusted bone measures Median 25OHD concentrations were similar 173 ng/mL in the vitamin D3 supplementation group vs 156 ng/mL in the placebo group and both groups had mild bone deficits At 12 months 25OHD rose significantly in the vitamin D supplementation group but not in the placebo group 264 vs 148 ng/mL respectively p 0008 After adjusting for population ancestry sex antiretroviral therapy use and season there were no significant treatment group differences in bone or body composition outcomesWe are grateful to the study participants and their families We would like to thank Julia L Samuel and Savannah Knell as the lead study staff members In addition we would like to acknowledge the Clinical Translational Research Center the Special Immunology Family Care Clinic Adolescent Initiative Program at CHOP Jonathan Lax Treatment Center Cooper University Hospital Alfred I duPont Hospital for Children Hospital of the University of Pennsylvania Temple University Hospital and Drexel University HospitalThis work was supported by the NIH/National Center for Complementary and Alternative Medicine Grant R01AT005531 the National Center for Research Resources Grant UL1RR024134 and is now at the National Center for Advancing Translational Sciences Grant UL1TR000003 The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH This publication was made possible through core services and support from the University of Pennsylvania Center for AIDS Research an NIHfunded program P30AI045008 Additional support was from the Jean A Cortner Endowed Chair Nutrition Center and the Research Institute at the Children’s Hospital of Philadelphia Life Extension Ft Lauderdale FL and JR Carlson Laboratories Inc Arlington Heights IL donated the vitamin D3 supplements and placebo capsules and drops respectively
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