Authors: J Narváez
Publish Date: 2012/05/12
Volume: 24, Issue: 2, Pages: 737-737
Abstract
We thank Drs Subramanian and Quek for their interest in our article 1 We agree that concomitant drug therapy may offset the benefits of teriparatide treatment However their last two observations are speculative In the six reported cases documenting the efficacy of teriparatide in ONJ resistant to conventional therapy the clinical and radiological improvement was clear Monitoring biochemical markers of bone remodelling or the use of SPECT/CT was unnecessary The seeming improvement claimed to have been detectable is debatable and was not detectable in CT studies performed before and after treatment in over 350 contiguous slices of 065 mm There may be a role for teriparatide in the management of ONJ but the evidence in support of its use is limited to a small number of cases level of evidence 4 according to the EvidenceBased Medicine Oxford classification To be able to obtain firmer conclusions we suggest further studies are needed
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