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Title of Journal: Osteoporos Int

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Abbravation: Osteoporosis International

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Springer-Verlag

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DOI

10.1016/0378-4371(88)90069-6

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1433-2965

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Systemic treatment with strontium ranelate promote

Authors: Y F Li E Luo G Feng S S Zhu J H Li J Hu
Publish Date: 2009/12/03
Volume: 21, Issue: 11, Pages: 1889-1897
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Abstract

Systemic treatment with strontium ranelate SR was performed on ovariectomized OVX rats with fractured tibiae Callus quality was assessed by radiographic histological microcomputerized tomography and biomechanical examinations at 4 and 8 weeks after fracture Results revealed that systemic applied SR promoted osteoporotic fracture healingSeveral studies have demonstrated the dual effect of SR on osteoporotic and undisturbed bone However reports of their effect on osteoporotic fracture healing are limited This study was designed to investigate the effects of SR on bone regeneration in OVX rats with fractured tibiaeThree months after being OVX female Sprague–Dawley rats accepted bilateral osteotomy on proximal tibiae fixed with intramedullary wires and were divided into two groups OVX and OVX + SR 625 mg/kg/day Callus quality was evaluated at 4 and 8 weeks postfractureCompared with OVX group SR treatment significantly increased bone formation BMD biomechanical strength and improved microstructural properties of the callus The ultimate load was increased by 2110 and 614 p  001 and the total bone volume of callus by 748 and 793 p  001 at 4 and 8 weeks postfracture respectively SR treatment also promoted healing progress with increased osteogenesis at 4 weeks more mature and tightly arranged woven or lamellar bone at 8 weeks across the fracture gap in histological analysis

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