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Title of Journal: Osteoporos Int

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Abbravation: Osteoporosis International

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Springer-Verlag

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DOI

10.1007/bf00053531

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1433-2965

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Quantitative ultrasound and fracture risk predicti

Authors: M Y Chan N D Nguyen J R Center J A Eisman T V Nguyen
Publish Date: 2012/08/10
Volume: 24, Issue: 3, Pages: 1015-1022
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Abstract

This study sought to determine the association between calcaneal quantitative ultrasound QUS and fracture risk in individuals without osteoporosis according to the World Health Organization criteria ie BMD Tscore  −25 We found that calcaneal QUS is an independent predictor of fracture risk in women with nonosteoporotic bone mineral density BMDMore than 50  of women and 70  of men who sustain a fragility fracture have BMD above the osteoporotic threshold Tscore  −25 Calcaneal QUS is associated with fracture risk This study aimed to test the hypothesis that low calcaneal QUS is associated with increased fracture risk in individuals with nonosteoporotic BMDWe included 312 women and 390 men aged 62–90 years with BMD Tscore  −25 at femoral neck QUS was measured in broadband ultrasound attenuation BUA at the calcaneus using a CUBA sonometer BMD was measured at the femoral neck FNBMD by dual energy Xray absorptiometry using GE Lunar DPXL densitometer The incidences of any fragility fracture were ascertained by Xray reports during the followup period from 1994 to 2011Of the 702 participants 26  of women n = 80/312 and 14  of men n = 53/390 experienced at least one fragility fracture during the followup period In women after adjusting for covariates increased risk of any fracture was significantly associated with decreased BUA HR = 150 95  CI 113–199 Compared with that of FNBMD the models with BUA in women had greater AUC 071 085 071 for any hip and vertebral fracture respectively and yielded a net reclassification improvement of 164  P = 0009 when combined with FNBMD In men BUA was not significantly associated with fracture risk before and after adjustmentWe gratefully acknowledge the assistance of Sr Janet Watters Donna Reeves and Shaye Field for the interview data collection and measurement of bone mineral density We also appreciate the invaluable help of the staff of Dubbo Base Hospital We thank Mr J McBride Dania Mang and the IT group of the Garvan Institute of Medical Research for the management of the database The study was partly supported by the Australia National Health and Medical Research Council NDN is supported by a fellowship from the AMBeR Australian Medical Bioinformatics Resource TVN is supported by a senior research fellowship from the Australian National Health and Medical Research CouncilProfessor JA Eisman has served as consultant on the Scientific Advisory Board for Amgen Eli Lilly Merck Sharp Dohme Novartis SanofiAventis Servier and deCode He was the editorinchief for the Journal of Bone and Mineral Research from 2003 to 2007 and was a committee member of Department of Health and Aging Australian Government and Royal Australasian College of General Practitioners Dr Jacqueling R Center has given educational talks for Eli Lilly Merck Sharp and Dohme and SanofiAventis Professor TV Nguyen has received honorarium for consulting and speaking in symposia sponsored by MSD Roche Servier SanofiAventis and Novartis Other authors have no conflicts of interest


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  2. Morbidity following lower extremity fractures in men with spinal cord injury
  3. DXA-based hip structural analysis of once-weekly bisphosphonate-treated postmenopausal women with low bone mass
  4. Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women
  5. Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures
  6. Evaluation of three risk assessment tools in discriminating fracture status among Chinese patients undergoing hemodialysis
  7. Oral bisphosphonates and risk of ischemic stroke: a case–control study
  8. The association between serum osteocalcin levels and metabolic syndrome in Koreans
  9. Place of residence and risk of fracture in older people: a population-based study of over 65-year-olds in Cardiff
  10. Fracture risk and adjuvant hormonal therapy among a population-based cohort of older female breast cancer patients
  11. Cost-utility of long-term strontium ranelate treatment for postmenopausal osteoporotic women
  12. Effects of therapeutic exercise for persons with osteoporotic vertebral fractures: a systematic review
  13. Genetic analysis of serum osteocalcin and bone mineral in multigenerational Afro-Caribbean families
  14. Effect of hospitalist consultation on treatment of osteoporosis in hip fracture patients
  15. Declining incidence of low-trauma knee fractures in elderly women: nationwide statistics in Finland between 1970 and 2006
  16. Changing health behaviors with social marketing
  17. Selective protein depletion impairs bone growth and causes liver fatty infiltration in female rats: prevention by Spirulina alga
  18. The vertebral fracture cascade in osteoporosis: a review of aetiopathogenesis
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  31. Economic burden of privately insured non-vertebral fracture patients with osteoporosis over a 2-year period in the US
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  40. Clinical characteristics and risk factors of postoperative pneumonia after hip fracture surgery: a prospective cohort study
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  42. Serum sclerostin: the missing link in the bone-vessel cross-talk in hemodialysis patients?
  43. Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw: reply to Subramanian and Quek
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  45. Intervention thresholds for osteoporosis in men and women: a study based on data from Sweden
  46. Influence of fall related factors and bone strength on fracture risk in the frail elderly
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  48. Effects of alendronate and vitamin D in patients with normocalcemic primary hyperparathyroidism
  49. Stroke in relation to use of raloxifene and other drugs against osteoporosis
  50. Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women
  51. The relationship between low bone mass and metabolic syndrome in Korean women
  52. Effect of high-dose cholecalciferol (vitamin D 3 ) on bone and body composition in children and young adults with HIV infection: a randomized, double-blind, placebo-controlled trial
  53. Initiation of anti-osteoporotic therapy in patients with recent fractures: a nationwide analysis of prescription rates and persistence
  54. Treatment of osteoporosis after alendronate or risedronate
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  56. Estrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women
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  58. Fracture Reduction Affects Medicare Economics (FRAME): Impact of increased osteoporosis diagnosis and treatment
  59. Low skeletal muscle mass associates with low femoral neck strength, especially in older Korean women: the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV)
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