Authors: M L Gourlay J M Powers LY Lui K E Ensrud for the Study of Osteoporotic Fractures Research Group
Publish Date: 2008/01/25
Volume: 19, Issue: 8, Pages: 1175-1183
Abstract
Clinical performance of osteoporosis risk assessment tools was studied in women aged 67 years and older Weight was as accurate as two of the tools to detect low bone density Discriminatory ability was slightly better for the OST risk tool which is based only on age and weightWe conducted a diagnostic accuracy analysis of the Osteoporosis Selfassessment Tool OST Osteoporosis Risk Assessment Instrument ORAI Simple Calculated Osteoporosis Risk Estimation SCORE and individual risk factors age weight or prior fracture to identify low central hip and lumbar spine bone mineral density BMD in 7779 US women aged 67 years and older participating in the Study of Osteoporotic FracturesThe OST had the greatest area under the receiver operating characteristic curve AUC 076 95 CI 074 077 Weight had an AUC of 073 95 CI 072 075 which was ≥AUC values for the ORAI SCORE age or prior fracture Using cut points from the development papers the risk tools had sensitivities ≥85 and specificities ≤48 When new cut points were set to achieve a likelihood ratio of negative 01–02 the tools ruled out fewer than 1/4 of women without low central BMDThe project described was funded by Grant Number K23RR024685 from the National Center for Research Resources and by the University of North Carolina Translational Science Program The Study of Osteoporotic Fractures SOF is supported by the National Institutes of Health Public Health Service research grants AG05407 AR35582 AG05394 AR35584 AR35583 R01 AG005407 R01 AG02757622 2 R01 AG00539422A1 and 2 R01 AG02757422A1 The content is solely the responsibility of the authors and does not necessarily reflect the official views of the funding agencies
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