Associations among Lipids Leptin and Leptin Rece

Authors: CunZhi Han LiLi Du JieXian Jing XianWen Zhao FuGuo Tian Jing Shi BaoGuo Tian XiuYing Liu LiJiao Zhang

Publish Date: 2008/07/31

Volume: 126, Issue: 1-3, Pages: 38-48

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Abstract

We evaluated the relationship among the leptin receptor LEPR gene Gln223Arg polymorphism body mass index BMI waist and hip circumference ratio WHR dietary structure lifestyle and other biomarkers with breast cancer and determined whether they could be effective for the prevention and treatment of breast cancer The Gln223Arg polymorphisms in the LEPR gene were investigated in blood deoxyribonucleic acid DNA available for 240 breast cancer cases and 500 controls Genotyping was performed by polymerase chain reaction–restriction fragment length polymorphism Leptin insulin were determined by enzymelinked immunosorbent assays We found that the serum levels of leptin insulin triglyceride TG free cholesterol FCH apolipoprotain APO A1 and BMI were significantly higher in breast cancer cases than the controls while physical activity was clearly less in breast cancer cases P  002 ~ P  0001 respectively Moreover there were significant association between the Gln223Arg genotype and breast cancer risk homozygotes for AA and heterozygotes for AGAG + GG genotypes had been proved to increase the risk of breast cancer and their corresponding odds ratio were 714 95 confidence interval CI = 192–2564 13395 CI = 103–270 and 204 95 CI = 109–382 Interestingly logistic regression analysis showed that LEPR gene Gln223Arg polymorphism and elevated leptin insulin TG FCH APOA1 WHR and reduced APOB increased the risk of developing breast cancer respectively And it also suggested that LEPR gene Gln223Arg polymorphisms elevated leptin insulin TG FCH APOA1 WHR and reduced APOB should play a major role in the development of breast cancer

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