Journal Title
Title of Journal: Biol Trace Elem Res
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Abbravation: Biological Trace Element Research
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Authors: Emam A AbdelRahim Yasmin E AbdelMobdy Rhaam F Ali Hend A Mahmoud
Publish Date: 2014/07/13
Volume: 160, Issue: 3, Pages: 400-408
Abstract
The present work is aimed to investigate the toxicity of 1/20 LD50 of cadmium chloride CdCl2 on male albino rats by oral ingestion and to determine the hepatoprotective effect of Solanum nigrum Linn SN dried fruits and their ethanolic extract against CdCl2 toxicity using biochemical parameters Rats were divided into six groups the first group is control second group is CdCl2intoxicated rats third group is fed with a semimodified diet with S nigrum fruits fourth group rats ingested with dried extract and intoxicated rats groups 5 and 6 were treated with fruits and ethanolic extract of S nigrum respectively The results showed that rats exposed to CdCl2 induced remarkable decrease in body weight gain feed efficiency and Hb Hct RBC and WBC count and MCHC but increase in MCV and MCH values In the case of plasma enzymes there were significant stimulations observed in ALT and AST acid phosphatase alkaline phosphatase and LDH activities of CdCl2intoxicated rats group 2 compared to control group 1 Plasma protein profile showed decreases in total soluble protein and albumin also globulin content was decreased by CdCl2 ingestion Under the same condition plasma total bilirubin and glucose levels were increased in group 2 In addition lipid peroxidation and antioxidative system GSH catalase and SOD of liver were harmed by CdCl2 ingestion Whereas normal rats treated with SN showed insignificant changes in groups 3 and 4 as compared to control group 1 The treatment with dried fruits and their ethanolic extract in CdCl2intoxicated rats groups 5 and 6 ameliorated and improved these harmful effects in all above parameters either for blood or liver The results of this study suggest the protective effect of S nigrum against liver injury happened by CdCl2 which may be attributed to its hepatoprotective activity and thereby
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