Magnesium Supplementation Prevents and Reverses Ex

Authors: Maikel Kronbauer Hecson J Segat Caren Tatiane De David Antoniazzi Karine Roversi Katiane Roversi Camila S Pase Raquel CSBarcelos Marilise E Burger

Publish Date: 2015/02/18

Volume: 166, Issue: 2, Pages: 163-172

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Abstract

Reserpine administration results in a predictable animal model of orofacial dyskinesia OD that has been largely used to access movement disturbances related to extrapyramidal oxidative damage Here OD was acutely induced by reserpine two doses of 07 mg/kg subcutaneous sc every other day for 3 days which was administered after experiment 1 and before experiment 2 magnesium Mg supplementation 40 mg/kg/mL peroral po In experiment 1 Mg was administered for 28 days before reserpine treatment while in experiment 2 it was initiated 24 h after the last reserpine administration and was maintained for 10 consecutive days Experiment 1 prevention showed that Mg supplementation was able to prevent reserpineinduced OD and catalepsy development Mg was also able to prevent reactive species RS generation thus preventing increase of protein carbonyl PC levels in both cortex and substantia nigra but not in striatum Experiment 2 reversion showed that Mg was able to decrease OD and catalepsy at all times assessed In addition Mg was able to decrease RS generation with lower levels of PC in both cortex and striatum but not in substantia nigra These outcomes indicate that Mg is an important metal that should be present in the diet since its intake is able to prevent and minimize the development of movement disorders closely related to oxidative damage in the extrapyramidal brain areas such as OD

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