Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Biol Trace Elem Res

Search In Journal Title:

Abbravation: Biological Trace Element Research

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1002/ange.19630750341

Search In DOI:

ISSN

1559-0720

Search In ISSN:
Search In Title Of Papers:

Developmental Hypothyroxinemia and Hypothyroidism

Authors: Yuan Wang Jing Dong Yi Wang Wei Wei Binbin Song Zhongyan Shan Weiping Teng Jie Chen
Publish Date: 2016/03/31
Volume: 173, Issue: 2, Pages: 465-474
PDF Link

Abstract

Iodine is a significant micronutrient Iodine deficiency IDinduced hypothyroxinemia and hypothyroidism during developmental period can cause cerebellar dysfunction However mechanisms are still unclear Therefore the present research aims to study effects of developmental hypothyroxinemia caused by mild ID and hypothyroidism caused by severe ID or methimazole MMZ on parallel fiber–Purkinje cell PFPC synapses in filial cerebellum Maternal hypothyroxinemia and hypothyroidism models were established in Wistar rats using ID diet and deionized water supplemented with different concentrations of potassium iodide or MMZ water Birth weight and cerebellum weight were measured We also examined PFPC synapses using immunofluorescence and western blot analysis was conducted to investigate the activity of Neurexin1/cerebellin1 Cbln1/glutamate receptor d2 GluD2 tripartite complex Our results showed that hypothyroxinemia and hypothyroidism decreased birth weight and cerebellum weight and reduced the PFPC synapses on postnatal day PN 14 and PN21 Accordingly the mean intensity of vesicular glutamate transporter VGluT1 and Calbindin immunofluorescence was reduced in mild ID severe ID and MMZ groups Moreover maternal hypothyroxinemia and hypothyroidism reduced expression of Neurexin1/Cbln1/GluD2 tripartite complex Our study supports the hypothesis that developmental hypothyroxinemia and hypothyroidism reduce PFPC synapses which may be attributed to the downregulation of Neurexin1/Cbln1/GluD2 tripartite complexJie Chen and Weiping Teng conceived and designed the study Yuan Wang Jing Dong Yi Wang Wei Wei Binbin Song performed the experiments Weiping Teng and Jie Chen obtained funding and ethics approval Yuan Wang Jing Dong Yi Wang Zhongyan Shan and Jie Chen analyzed the data Yuan Wang wrote the article in whole Jing Dong Yi Wang and Jie Chen revised the article

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Determination of Lead in Biological Samples of Children with Different Physiological Consequences Using Cloud Point Extraction Method
  2. The Association Between Arsenic and Children’s Intelligence: A Meta-analysis
  3. Daily Intake of Magnesium and its Relation to Urinary Excretion in Korean Healthy Adults Consuming Self-Selected Diets
  4. Effects of Boric Acid on Fracture Healing: An Experimental Study
  5. Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length
  6. Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model
  7. Effects of Cr Methionine on Glucose Metabolism, Plasma Metabolites, Meat Lipid Peroxidation, and Tissue Chromium in Mahabadi Goat Kids
  8. Effects of Dietary Factors on Selenium Levels of Children to Prevent Kashin–Beck Disease During a High-Prevalence Period in an Endemic Area: a Cohort Study
  9. Effects of Chromium Methionine Supplementation with Different Sources of Zinc on Growth Performance, Carcass Traits, Meat Quality, Serum Metabolites, Endocrine Parameters, and the Antioxidant Status in Growing-Finishing Pigs
  10. Evaluating the Suitability of Postnuclear Supernatants as In Vitro Models for Assessing Cadmium- and Other Xenobiotic-Induced Neurotoxicity on Crucial Enzymatic Parameters
  11. The importance of boron nutrition for brain and psychological function
  12. Effects of Restraint Stress on Iron, Zinc, Calcium, and Magnesium Whole Blood Levels in Mice
  13. Effects of Restraint Stress on Iron, Zinc, Calcium, and Magnesium Whole Blood Levels in Mice
  14. Proximate and Elemental Composition of Chamelea gallina from the Southern Coast of the Marmara Sea (Turkey)
  15. Antibacterial Evaluation of Novel Organoarsenic Compounds by the Microcalorimetric Method
  16. Analysis of Ionomic Profiles of Canine Hairs Exposed to Lipopolysaccharide (LPS)-Induced Stress
  17. Does Iodine Biofortification Affect Oxidative Metabolism in Lettuce Plants?
  18. Selenium Deficiency Influences Nitric Oxide and Selenoproteins in Pancreas of Chickens
  19. Effects of Astragalus membranaceus with Supplemental Calcium on Bone Mineral Density and Bone Metabolism in Calcium-Deficient Ovariectomized Rats
  20. Magnesium Supplementation Prevents and Reverses Experimentally Induced Movement Disturbances in Rats: Biochemical and Behavioral Parameters
  21. Environmental Cadmium Exposure Impacts Physiological Responses in Manila clams
  22. Effect of Zinc-Bearing Zeolite Clinoptilolite on Growth Performance, Nutrient Retention, Digestive Enzyme Activities, and Intestinal Function of Broiler Chickens
  23. Exogenously Treated Mammalian Sex Hormones Affect Inorganic Constituents of Plants
  24. Effects of Different Levels of Organic and Inorganic Chromium on Growth Performance and Immunocompetence of Broilers under Heat Stress
  25. Hepatoprotective Effects of Solanum nigrum Linn Fruits Against Cadmium Chloride Toxicity in Albino Rats
  26. Fluorescent Protein-Based Optical Biosensor for Copper Ion Quantitation
  27. Anaemia, Folate, Zinc and Copper Deficiencies Among Adolescent Schoolgirls in Eastern Sudan
  28. Biochemical, Histological, and Memory Impairment Effects of Chronic Copper Toxicity: A Model for Non-Wilsonian Brain Copper Toxicosis in Wistar Rat
  29. Effects of Oxidized Cooking Oil and α-Lipoic Acid on Blood Antioxidants: Enzyme Activities and Lipid Peroxidation in Rats Fed a High-Fat Diet
  30. Associations among Lipids, Leptin, and Leptin Receptor Gene Gin223Arg Polymorphisms and Breast Cancer in China
  31. Associations among Lipids, Leptin, and Leptin Receptor Gene Gin223Arg Polymorphisms and Breast Cancer in China
  32. Effects of Selenium and Low Levels of Lead on Mammary Tumor Development and Growth in MMTV-infected Female Mice
  33. Preparation and Biological Effect of Nucleotide-Capped CdSe/ZnS Quantum Dots on Tetrahymena thermophila
  34. Supplementation with Organic or Inorganic Selenium in Heat-distressed Quail
  35. Functional Improvement in Rats’ Pancreatic Islets Using Magnesium Oxide Nanoparticles Through Antiapoptotic and Antioxidant Pathways
  36. Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases
  37. Role of Synthesized Organoselenium Compounds on Protection of Rat Erythrocytes from DMBA-Induced Oxidative Stress
  38. Dietary Silicon Intake of Korean Young Adult Males and Its Relation to their Bone Status
  39. Microarchitecture and Nanomechanical Properties of Trabecular Bone After Strontium Administration in Osteoporotic Goats
  40. Boron Affects Immune Function Through Modulation of Splenic T Lymphocyte Subsets, Cytokine Secretion, and Lymphocyte Proliferation and Apoptosis in Rats
  41. Protective Role of Selenium on Aflatoxin B 1 -Induced Hepatic Dysfunction and Apoptosis of Liver in Ducklings
  42. Effects of Nano-anatase TiO 2 on Absorption, Distribution of Light, and Photoreduction Activities of Chloroplast Membrane of Spinach
  43. Pharmacokinetics, Tissue Distribution, and Plasma Protein Binding Study of Platinum Originating from Dicycloplatin, a Novel Antitumor Supramolecule, in Rats and Dogs by ICP-MS
  44. Effects of Selenium and Cadmium on Ion Profiles in the Brains of Chickens
  45. NAA-SLR and ICP-AES Application in the Assessment of Mass Fraction of 19 Chemical Elements in Pediatric and Young Adult Prostate Glands
  46. Fluoride Content in Alcoholic Drinks
  47. A Mineral and Antioxidant-Rich Extract from the Red Marine Algae Alsidium corallinum Exhibits Cytoprotective Effects Against Potassium Bromate-Induced Erythrocyte Oxidative Damages in Mice
  48. Comparison of a Modified Hemoglobin Regeneration Efficiency Method with a Slope-Ratio Assay in Measuring Relative Bioavailability of Cocoa Powder Iron Using Rats
  49. The Relationship Between Serum Levels of Zn and Cu and Severity of Coronary Atherosclerosis
  50. Subchronic Arsenic Exposure Through Drinking Water Alters Vascular Redox Homeostasis and Affects Physical Health in Rats
  51. Cadmium Accumulation and Metallothionein Response in the Freshwater Bivalve Corbicula fluminea Under Hydrodynamic Conditions
  52. Effect of Gestational Intake of Fisetin (3,3′,4′,7-Tetrahydroxyflavone) on Developmental Methyl Mercury Neurotoxicity in F 1 Generation Rats
  53. RETRACTED ARTICLE: Serum Zinc and Adiponectin Levels in Patients with Polycystic Ovary Syndrome, Adjusted for Anthropometric, Biochemical, Dietary Intake, and Physical Activity Measures
  54. Effect of Zinc Ions on Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells to Male Germ Cells and Some Germ Cell-Specific Gene Expression in Rams
  55. Protective Effects of Mangiferin in Subchronic Developmental Lead-Exposed Rats
  56. Acute Cadmium Exposure Reduces the Local Angiotensin I Converting Enzyme Activity and Increases the Tissue Metal Content
  57. Dietary Manganese Supplementation Influences the Expression of Transporters Involved in Iron Metabolism in Chickens
  58. Protective Effect of Cerium Ion Against Ultraviolet B Radiation-Induced Water Stress in Soybean Seedlings
  59. The Effect of c-Fos Demethylation on Sodium Fluoride-induced Apoptosis in L-02 Cells
  60. The Effect of Severe Zinc Deficiency and Zinc Supplement on Spatial Learning and Memory
Search Result: