Journal Title
Title of Journal: Biol Trace Elem Res
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Abbravation: Biological Trace Element Research
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Publisher
Humana Press Inc
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Authors: SeChan Kang Hee Jung Kim MiHyun Kim
Publish Date: 2012/11/09
Volume: 151, Issue: 1, Pages: 68-74
Abstract
It has been reported that Astragalus membranaceus an Asian traditional herb has an estrogenic effect in vitro To examine the possible role of A membranaceus extract with supplemental calcium Ca on bone status in calciumdeficient LCa ovariectomized OVX rats a total of 48 female rats were divided into six groups 1 normal control 2 sham operation with LCa shamLCa 3 OVX with LCa OVXLCa 4 A membranaceus supplementation with OVXLCa OVXMLCa 5 Ca supplementation with OVX OVXCa and 6 A membranaceus and Ca supplementation with OVX OVXMCa A membranaceus ethanol extract 500 mg/kg BW and/or Ca 800 mg/kg BW were administered orally for 8 weeks along with a Cadeficient diet Results revealed that Ca supplementation with or without A membranaceus extract significantly improved bone mineral density biomechanical strength and ash weight of the femur and tibia in OVX rats High Ca with A membranaceus combination supplementation significantly increased the ash weight of the femur and tibia and decreased urinary Ca excretion compared with supplementation of Ca alone Uterine weight was not changed by A membranaceus administration in OVX rats These results suggest that A membranaceus extract combined with supplemental Ca may be more protective against the Ca loss of bone than A membranaceus or supplementation of Ca alone in calciuminsufficient postmenopausal women
Keywords:
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