Effects of Boric Acid on Fracture Healing An Expe

Authors: Umut Hatay Gölge Burak Kaymaz Rabia Arpaci Erkam Kömürcü Ferdi Göksel Mustafa Güven Yunus Güzel Sibel Cevizci

Publish Date: 2015/04/07

Volume: 167, Issue: 2, Pages: 264-271

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Abstract

Boric acid BA has positive effects on bone tissue In this study the effects of BA on fracture healing were evaluated in an animal model Standard closed femoral shaft fractures were created in 40 male Sprague–Dawley rats under general anesthesia The rats were allocated into five groups n = 8 each group 1 control with no BA groups 2 and 3 oral BA at doses of 4 and 8 mg/kg/day respectively group 4 local BA 8 mg/kg and group 5 both oral and local BA 8 mg/kg/day orally and 8 mg/kg locally After closed fracture creation the fracture line was opened with a miniincision and BA was locally administered to the fracture area in groups 4 and 5 In groups 2 3 and 5 BA was administered by gastric gavage daily until sacrifice The rats were evaluated by clinical radiological and histological examinations The control group group 1 significantly differed from the local BAexposed groups groups 4 and 5 in the clinical evaluation Frontrear and lateral radiographs revealed significant differences between the local BAexposed groups and the control and other groups p  005 Clinical and radiological evaluations demonstrated adequate agreement between observers The average histological scores significantly differed across groups p = 0007 and were significantly higher in groups 4 and 5 which were the local BA 8 mg/kg and both oral and local BA 8 mg/kg/day orally and 8 mg/kg locally respectively compared to the controls This study suggests that BA may be useful in fracture healing Further research is required to demonstrate the most effective local dosage and possible use of BAcoated implants

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