Effects of Dietary Factors on Selenium Levels of C

Authors: Y J Ning X Wang L Ren X Guo

Publish Date: 2013/04/09

Volume: 153, Issue: 1-3, Pages: 58-68

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Abstract

Selenium Se supplements have been used to control Kashin–Beck disease KBD for decades but the effect of diet without Se supplements is unclear because the prevalence of KBD has decreased This matched cohort study was undertaken to determine dietary factors affecting selenium nutrition status of children living in KBD areas and the effects of Se supplements in preventing KBD A total of 593 children aged 5–12 years were randomly selected during the high prevalence period of KBD from 1992 to 1995 Children in one village received Se supplemented Se+ salt and were matched with three children in 16 other villages who did not receive Se supplemented Se− salt A questionnaire and determinations of occipital hair Se to reflect body Se status were obtained at baseline April 1992 at 6 months October 1992 and yearly each April through 1995 Hair Se content in the Se+ group was significantly higher than in the Se− group P  0001 at all timepoints and was significantly related to the incidence of suspected KBD symptoms P = 0018 Four dietary factors significantly affected hair Se contents Se levels were increased by consumption of Se+ salt P  0001 and eating meat/egg often P = 0019 or occasionally P = 0001 Se levels were decreased by consumption of grain mildewed at harvest or in storage P  0001 for each and drinking ditch river or cellar water P  0001 P = 0002 P  0001 respectively These results show that Se+ salt had a significant effect in maintaining the Se nutrition status of children in this cohort study but that dietary factors in those without Se supplements contributed as wellWe appreciate the Bin and Yongshou CDC for their outstanding support in the collection of hair samples We are also grateful to Dexiu Ding Shiyan Zhang Zhilun Wang Xiwang Tan Jianjun Zhang Huayin Bi Xiaoyan Mo Sichun Li Xue Li and Dong Geng for their best work of questionnaire enquiry Zhidao Yu and Fengshi Chen for the determinations of hair Se content and Jiuxing Wang for collecting Xray images of the children’s right hands This work was supported in part by the National Natural Scientific Foundation of China 30972556 the“13115” major program of the Technology Science Innovation Project of Shann’xi Province 2009ZDKG79 and a grant from the Medical Program of the EighthFive National Plan for Science and Technology in China 859170102

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