Role of Synthesized Organoselenium Compounds on Pr

Authors: Zeliha Selamoglu Talas Ismet Yilmaz Ilknur Ozdemir Burhan Ates Yetkin Gok Bekir Cetinkaya

Publish Date: 2008/10/31

Volume: 128, Issue: 2, Pages: 167-175

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Abstract

Formation of free radicals is not limited to normal cellular process but also occur upon exposure to certain chemicals polycyclic aromatic hydrocarbon cadmium lead etc cigarette smoke radiation and highfat diet Freeradical damage is an important factor in many pathological and toxicological processes Selenium an essential micronutrient is a associated with antioxidant functions physiological defense mechanisms against different diseases including several types of cancers Search for new selenium compounds with more chemopreventive activities and less toxicities are in progress In addition there has been a growing interest in the synthesis of organoselenium compounds with respect to their use in enzymology and bioorganic chemistry In the present study adult female Wistar rats were treated with 712dimethylbenzaanthracene DMBA and the organoselenium compounds 1isopropyl3methylbenzimidazole2selenone Se I and 1 3dipmethoxybenzylpyrimidine2selenone Se II in determined doses The protective effects of synthetic organoselenium compounds Se I and Se II against DMBAinduced changes in antioxidant enzyme superoxide dismutase glutathione peroxidase GSHPx catalase CAT glutathione reductase GR activities total GSH and malondialdehyde MDA levels of rat erythrocyte were investigated The DMBAtreated group exhibited significant decreases in the levels of erythrocyte GSHPx CAT and GR activities an increase in MDA levels and a decrease in total GSH level compared to the control Se I and Se II fully or partially restored enzyme activity Lipid peroxidation was also decreased in SeI and SeIItreated groups

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