Authors: XinYou Chen XinLiang Hu CaiFen Xia CaiQin Qin Yi Liu
Publish Date: 2013/04/20
Volume: 153, Issue: 1-3, Pages: 382-389
Abstract
Antibacterial activities of novel organoarsenic compounds AsIIIcontaining Schiff bases on Escherichia coli CCTCCAB91112 were investigated by microcalorimetry in this study The experimental result showed that the arsenicIIIcontaining Schiff bases at micromolar concentration exhibit strong inhibition on the E coli Specifically the growth rate constant k decreased and the generation time t G and the inhibitory ratio I percentage increased with the increased dose of the arsenicals as inhibitors All of the arsenicals display the feature of considerable lag phase inhibition on the cell growth The compound 44bromobenzaliminylphenylarsenoxide makes the lag phase of E coli cell growth cycles to reach 650 min at 5 μmol/L The compounds with donating electron groups at aromatic ring B have lower IC50 to present higher antibacterial activity The compound 44hydroxyl3methoxylbenzaliminylphenylarsenoxide has the lowest IC50 182 μmol/L to show the strongest antibacterial activity among them
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