Protective Effects of Mangiferin in Subchronic Dev

Authors: HaoWen Li JiaGang Deng ZhengCai Du MaoSheng Yan ZhiXiang Long PhuongThao Pham Thi KeDi Yang

Publish Date: 2013/01/30

Volume: 152, Issue: 2, Pages: 233-242

PDF Link

Abstract

Lead is a ubiquitous environmental and industrial pollutant Exposure to excessive amounts of lead is especially harmful to the central nervous systems of infants and young children and oxidative stress has been reported as a major mechanism of leadinduced toxicity To evaluate the ameliorative potential of antioxidant mangiferin MGN on leadinduced toxicity Morris water maze test determination of blood and bone lead concentration determination of antioxidant status in plasma as well as observation of ultrastructural changes in the hippocampus were carried out In the present study under a transmission electron microscope ameliorated morphological damages in the hippocampus were observed in MGNtreated groups Blood and bone lead concentration in MGNtreated groups lowered to some extent p  005 p  001 The activities of antioxidant enzymes glutathione GSH content and the GSH/oxidized glutathione ratio in MGNtreated groups were increased respectively Further studies are needed to establish whether the observed differences were a direct cause of mangiferin on leadinduced toxicity or not This study might provide clues for the treatment of leadinduced toxicity

Keywords: