Pharmacokinetics Tissue Distribution and Plasma

Authors: Di Zhao Yongjie Zhang Chunxiang Xu Can Dong Hui Lin Lingli Zhang Cuiyun Li Shuangxia Ren Xin Wang Shuoye Yang Deen Han Xijing Chen

Publish Date: 2012/02/28

Volume: 148, Issue: 2, Pages: 203-208

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Abstract

Dicycloplatin as a new antitumor supramolecule was considered to have higher solubility and higher stability compared with carboplatin The aim of the present study was to evaluate the pharmacokinetic characteristics of platinum originating from dicycloplatin A rapid sensitive and specific method with inductively coupled plasma mass spectrometry ICPMS has been developed for the determination of platinum in biosamples The study was performed in male rats and dogs at a single dose of 10 and 5 mg kg−1 separately by intravenous injection Pharmacokinetic parameters were calculated by noncompartmental method and the dose of platinum was used in the calculation of these parameters Results showed that plasma concentrations of platinum began to decrease rapidly initially but decline slowly with a long terminal phase The mean halflife was 2739 and 10098 and clearance was 077 and 008 L/h/kg for rats and dogs separately Tissue distribution showed that platinum originating from dicycloplatin had a certain distribution in testis and prostate Plasma protein binding proportion of platinum was increased with time In conclusion this research investigated the pharmacokinetic characteristics including plasma kinetics tissue distribution and plasma protein binding of platinum originating from dicycloplatin in rats and dogs in detail for the first time by ICPMS

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