Authors: Apostolos Zarros Ryan T Cameron Stylianos Tsakiris George S Baillie
Publish Date: 2013/02/14
Volume: 152, Issue: 3, Pages: 297-299
Abstract
Govil et al 1 have recently provided an interesting report on the use of murine brainderived postnuclear supernatants as an in vitro model for the assessment of neurotoxic effects of cadmium Cd The authors focus on an important topic within the neurotoxicity arena and describe an extensive neurochemical screening via the study of the in vitro effects of different Cdchloride CdCl2 concentrations 1 5 and 10 mM on the following crucial enzymatic and nonenzymatic parameters catalase activity superoxide dismutase activity glutathioneStransferase activity acetylcholinesterase AChE activity sodium–potassium adenosinetriphosphatase Na+ K+ATPase activity reduced glutathione content and thiols content analysis 1 It is our opinion that the methodology used by the authors for the neurochemical analysis is appropriate and so is the studied biomarker selection However there are certain important issues addressed within this report 1 on which we would like to
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