Boron Affects Immune Function Through Modulation o

Authors: Erhui Jin Shenghe Li Man Ren Qianqian Hu Youfang Gu Kui Li

Publish Date: 2017/01/14

Volume: 178, Issue: 2, Pages: 261-275

PDF Link

Abstract

This study demonstrated the mechanisms of boron effects in a rat model and provided a scientific basis for the rational of boron use These findings were achieved by investigating the effects of boron 10 20 40 80 160 320 and 640 mg/L in drinking water or 15 3 6 12 24 48 and 96 mg/kg BW on rat serum immunoglobulins IgGs splenic cytokines lymphocyte subsets as well as on lymphocyte proliferation and apoptosis Addition of 20 3 and 40 6 mg/L mg/kg BW of boron to drinking water significantly increased rat serum IgG concentrations splenic IFNγ and IL4 expression as well as the number of splenic CD3+ CD4+ and proliferating cell nuclear antigen PCNA+ cells Supplementation of drinking water with 40 mg/L 6 mg/kg BW boron also markedly increased splenic IL2 expression and the CD4+/CD8+ cell ratio and reduced splenic CD8+ cell number Supplementation with 80 mg/L 12 mg/kg BW boron significantly increased CD3+ and PCNA+ cell numbers P  005 and decreased the IL10 expression in the spleen Addition of 320 48 and 640 96 mg/L mg/kg BW boron markedly reduced the serum IgG concentrations splenic IL2 and IL10 expression the number of CD3+ CD4+ and PCNA+ cells and increased the number of splenic CD8+ and caspase3+ cells and promoted caspase3 expression in CD3+ cells In conclusion these findings suggest that the supplementation of rat drinking water with 203 and 406 mg/L mg/kg BW boron can markedly enhance humoral and cellular immune functions while boron concentrations above 320 mg/L 48 mg/kg BW can have an inhibitory effect or even toxicity on immune functions These results exhibit a Ushaped response characteristic of low and high doses of boron supplementation on immune function and imply that proper boron supplementation in food for humans and animals could be used as an immunity regulator

Keywords: