Journal Title
Title of Journal: Biol Trace Elem Res
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Abbravation: Biological Trace Element Research
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Authors: Hajer Ben Saad Imen Nasri Awatef Elwej Najeh Krayem Raoudha Jarraya Choumous Kallel Najiba Zeghal Ibtissem Ben Amara
Publish Date: 2014/06/10
Volume: 160, Issue: 1, Pages: 85-96
Abstract
The present study was carried out to investigate potassium bromate toxicity in mice and the corrective effects of marine algae Alsidium corallinum The red algae demonstrated its rich composition in phenols triterpenes flavonoids alkaloids tropolones sodium potassium calcium magnesium iron copper and zinc To confirm its antioxidant potential an in vivo study was performed on adult mice The animals were divided into four groups group I were used as controls group II received potassium bromate 05 g/L via drinking water group III received potassium bromate 05 g/L by the same route as group II and 7 of A corallinum ethanolic extract via their diet and group IV received only 7 of algae The potassium bromatetreated group showed a significant decrease in erythrocyte platelet hemoglobin and hematocrit values and a significant increase in total white blood cells compared to those of controls While superoxide dismutase catalase glutathione and vitamin C values were decreased by potassium bromate treatment lipid peroxidation as malondialdehyde and erythrocyte osmotic fragility values were increased Interestingly potassium bromate treatment showed significant genotoxic effects as demonstrated by DNA degradation These changes were confirmed by blood smears histopathological observations which were marked by a necrosis and a decrease of erythrocytes number A corallinum extract appeared to be effective against hematotoxic and genotoxic changes induced by potassium bromate as evidenced by the improvement of the parameters cited above
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