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Title of Journal: Biol Trace Elem Res

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Abbravation: Biological Trace Element Research

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Springer US

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DOI

10.1007/bf01234645

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ISSN

1559-0720

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Protective Role of Selenium on Aflatoxin BSubscri

Authors: Shenquan Liao Dayou Shi Connie L ClemonsChevis Shining Guo Rongsheng Su Panjia Qiang Zhaoxin Tang
Publish Date: 2014/10/02
Volume: 162, Issue: 1-3, Pages: 296-301
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Abstract

Aflatoxin B1 AFB1 is a mycotoxin which causes toxicity through oxidative damage Selenium Se an antioxidative agent can antagonize some toxicity induced by oxidative stress The aim of this work was to investigate the toxicity of AFB1 and the protective effects of Se on duckling liver in vivo The study consisted of three groups AFB1 AFB1Tx and a control group AFB1 group was administered aflatoxin intragastrically 01 mg/kg body weight AFB1Tx group was administered AFB1 intragastrically 01 mg/kg body weight plus sodium selenite 1 mg/kg body weight The control group was given the same volume of dimethyl sulfoxide DMSO via intragastric intubation All three groups received daily administrations for 28 days Blood samples were obtained on the 14th 21st and 28th days of postadministration and the serum alanine aminotransferase ALT and aspartate transaminase AST were evaluated A high level of serum ALT and AST was observed in AFB1 group The activity of ALT and AST was significantly lower in Se treatment group than those in AFB1 group Liver samples were collected on the 14th 21st and 28th days of postadministration and concentrations of Bcl2 Bax caspase3 and p53 were measured Increased expression level of Bax caspase3 and p53 and decreased Bcl2 expression level and Bcl2/Bax ratio were observed in AFB1 group Se diminished hepatic dysfunction or damage and modulated the expression of apoptotic related proteins in a timedependent manner In conclusion concurrent treatment with Se reduced the AFB1induced hepatic dysfunction and apoptosisThis work was supported by the National Natural Science Foundation of China Grant No 31302087 National TwelveFive Technological Supported Plan of China No 2011BAD34B01 and Science and Technology Plan Projects of Guangdong Province No 2012B091100482 2012B091100034

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  3. Daily Intake of Magnesium and its Relation to Urinary Excretion in Korean Healthy Adults Consuming Self-Selected Diets
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