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Title of Journal: Biol Trace Elem Res

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Abbravation: Biological Trace Element Research

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Humana Press Inc

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DOI

10.1007/bf00774235

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ISSN

1559-0720

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Preparation and Biological Effect of NucleotideCa

Authors: Qi Xiao Ting Qiu Shan Huang Yi Liu Zhike He
Publish Date: 2011/12/10
Volume: 147, Issue: 1-3, Pages: 346-353
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Abstract

In this paper we described the preparation and characterization of different types of modified CdSe/ZnS quantum dots QDs and explored the biological effects of QDs with different surface modifications on the whole growth of unicellular protozoan Tetrahymena thermophila BF5 using a thermal activity monitor air isothermal microcalorimeter Our results demonstrated that adenosine 5′monophosphate AMP showed stronger interaction with QDs than other types of nucleotide AMPQDs could stimulate the growth of T thermophila while mercaptoacetic acidcapped CdSe/ZnS quantum dots inhibited it In addition the population density determination and fluorescence imaging of T thermophila BF5 also confirmed the results obtained from microcalorimetry It is believed that this approach will provide a more convenient methodology for the kinetics and thermodynamics of microorganism when coexisting with QDs in real time and all of which are very significant to understanding the effect of QDs to organism

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