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Title of Journal: Microchim Acta

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Abbravation: Microchimica Acta

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Springer Vienna

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DOI

10.1007/bf00831846

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1436-5073

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Giant magnetoresistance based immunoassay for the

Authors: Xuecheng Sun Chong Lei Lei Guo Yong Zhou
Publish Date: 2016/01/12
Volume: 183, Issue: 3, Pages: 1107-1114
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Abstract

We report on a giant magnetoresistance GMR based immunosensor for the carcinoembryonic antigen CEA labeled with superparamagnetic microparticles Dynabeads The GMR sensor contains 200 GMR strips and was fabricated by microelectromechanical system MEMS technology This system can detect Dynabeads in concentrations down to 10 ng⋅mL−1 Sandwich immunoassays were employed on the surface of a gold film modified with a selfassembled monolayer and using biotinylated secondary antibody against CEA and streptavidinylated Dynabeads With DC magnetic fields in the range of 40 to 90 Oe CEA can be detected with a detection limit as low as 10 pg⋅mL−1 Samples spiked with different concentrations of CEA can be distinguished clearly and the method is deemed to be well suited for clinical useMake use of antigenantibody immune reaction Dynabeads that conjugated with polyclonal CEA antibodies were captured onto the surface of Au film which immobilize of monoclonal CEA antibodies Under the dc magnetic field magnetizing the superparamagnetism Dynabeads induced a weak magnetic field that can be detected by the nearby GMR sensor which reveals the presence of CEA GMR giant magnetoresistance CEA carcinoembryonic antigensThis work was supported by The National Natural Science Foundation of China No 61273065 National Science and Technology Support Program 2012BAK08B05 and National Key Laboratory Research Fund 9140C790403110C7905 Natural Science Foundation of Shanghai 13ZR1420800 Support fund of Joint research center for advanced aerospace technology of Shanghai Academy of Spaceflight TechnologyShanghai Jiao Tong University the Analytical and Testing Center in Shanghai Jiao Tong University the Center for Advanced Electronic Materials and Devices in Shanghai Jiao Tong University

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