Authors: G Rico E Leandro S Rojas J A Giménez R R Kretschmer
Publish Date: 2003/03/25
Volume: 90, Issue: 4, Pages: 264-267
Abstract
The monocyte locomotion inhibitory factor an antiinflammatory pentapeptide produced by Entamoeba histolytica inhibits the in vitro production of nitric oxide induced by cytokines INFγ TNFα or PMA in human leukocytes This can be added to the other previously reported functional effects of this factor such as the inhibition of monocyte locomotion and the synthesis of reactive oxygen intermediates in both monocytes and neutrophils The decreased nitric oxide production may interfere with the killing of amebas by neutrophils in the early invasive stages of amebiasis when oxidative mechanisms are used reactive oxygen and nitrogen intermediates either individually or synergistically via peroxynitrite ONOO– and in the advanced stages when both nonoxidative and oxidative including nitric oxide mechanisms are employed by macrophages Diminished nitric oxide production by leukocytes may also contribute to the paucity of late inflammatory components in amebic abscess of the liver and other amebic lesionsThis work was supported by CONACYT Mexico grant no 3206P9608 We thank Dr Ruy PérezTamayo UNAM for the critical review of the manuscript Ms Berenice Ramírez for the patient typing of the same and Mr Félix Rangel for his excellent art work The work was performed in compliance with the Ethical Research Committee of our institution IMSS and with the laws of the country
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