Authors: Flávia Aparecida Nogueira Lincoln Nunes Oliveira Rayana Brito da Silva Patrícia Silva Nery Gercino Ferreira Virgínio Luciana Castro Geraseev Eduardo Robson Duarte
Publish Date: 2012/02/10
Volume: 111, Issue: 1, Pages: 317-323
Abstract
Resistance to anthelminthics is common due to intensive and incorrect use In searching for alternatives extracts of banana plant were evaluated for egg hatching inhibition and fecal egg count reduction of sheep nematodes Aqueous extracts of the leaf pseudostem and heart of the banana plant cv Prata anã were tested at concentrations of 031 062 125 25 50 and 100 mg ml−1 in egg hatching inhibition tests For in vivo analysis aqueous extracts were evaluated at dosages calculated according to the 10 lethal dose derived from acute toxicity testing in mice Efficacy was evaluated at two time periods following oral administration For the banana extracts at 25 mg ml−1 egg hatching was significantly fewer than the negative control with an LC50 and LC90 of 019 and 084 mg ml−1 respectively In vivo analysis for weeks 1 and 2 following a single treatment with aqueous leaf extract showed 331 and 325 anthelminthic efficacy respectively Further research on higher dosages with more frequent administration is needed to evaluate the potential for utilizing banana plant residues in gastrointestinal nematode controlWe thank the Fundação de Amparo à Pesquisa de Minas Gerais FAPEMIG Banco do Nordeste and Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq of Brazil for providing financial support The authors are also grateful to Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES Brazil PRPq/UFMG and to Associação Central dos Fruticultores do Norte de Minas Abanorte
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