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Title of Journal: Parasitol Res

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Abbravation: Parasitology Research

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Springer-Verlag

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DOI

10.1016/0092-8674(84)90552-X

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1432-1955

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In vitro evaluation of the amebicidal activity of

Authors: Camila Ródio Damiana da Rocha Vianna Kreesla Passos Kowalski Lua Ferreira Panatieri Gilsane von Poser Marilise Brittes Rott
Publish Date: 2008/09/16
Volume: 104, Issue: 1, Pages: 191-194
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Abstract

The crude extract and hexane dichloromethane and methanol fractions obtained from the aerial parts of Pterocaulon polystachyum Asteraceae were assayed against Acanthamoeba castellanii a freeliving ameba that causes acute amebic keratitis Because of its capacity to form cysts some strains of this protozoan are excellent opportunists and therapy resistant necessitating a search for new drugs in order to develop more dynamic therapies that make it easier for patients to maintain longterm treatment In this context plants with medicinal properties have been analyzed The broadspectrum activity against a range of pathogenic fungi shown by extracts of P polystachyum together with the use of antifungal drugs as antiprotozoals made it important to evaluate the amebicidal activity of these plant extracts against A castellanii The greatest activity was observed in the treatment with the hexane fraction which lysed approximately 66 and 70 of the trophozoites in 48 and 72 h respectively preventing encystmentThe authors would like to thank CAPES and CNPq for financial support and Dr Naveed Khan School of Biological and Chemical Sciences Birkbeck College University of London for providing the A castellanii strain Dr Janet W Reid revised the English text

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