Authors: H A ElBanna A Goudah H ElZorba S AbdElRahman
Publish Date: 2008/02/23
Volume: 102, Issue: 6, Pages: 1337-1342
Abstract
This study investigated the comparative serum disposition kinetics of ivermectin IVM after a single subcutaneous dose of 200 μg/kg body weight of IVM alone or in combination with an anthelmintic consisting of ivermectin and rafoxanide 200 μg/kg of IVM and 25 mg/kg rafoxanide for use in calves and sheep The IVM concentrations in serum samples were analyzed by highperformance liquid chromatography with fluorescence detection In sheep serum rafoxanide induced a rapid absorption of IVM when given in combined form manifested by a shorter absorption halflife time of IVM by 6849 when given in combination as compared with IVM when given alone In addition there is an increase in the value of the area under the concentration curve AUC by 1548 while the value of elimination rate constant was decreased by 382 and significantly increased the halflife time of elimination from 204 days for IVM alone to 33 days when given in combination with rafoxanide In calves serum the mean t 1/2ab for IVM/rafoxanide was 0131 days and for the control formulation 016 days and t 1/2el was 578 and 495 respectively IVM C max for IVM/rafoxanide was 224 ng/ml and for the control formulation 191 ng/ml T max values were 099 and 112 days and the mean AUC values were 1889 and 1654 ng/ml/day The difference in C max AUC K ab K el and t 1/2el was significant However there was no statistical difference between the T max and t 1/2ab These findings revealed that the combination of rafoxanide with IVM in sheep and calves increased the absorption of IVM and delayed its elimination
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