Authors: Bikash Ranjan Giri Ravi Rao Bharti Bishnupada Roy
Publish Date: 2015/01/14
Volume: 114, Issue: 2, Pages: 785-788
Abstract
Anthelmintic resistance against most of the commercial drugs is a great threat to humans as well as the veterinary live stocks Hence new treatment strategies to control helminth infections are essential at this hour Carex baccans Nees has been traditionally used by Jaintia tribes in Northeast India to get rid of intestinal worm infections Therefore the present study was conducted to evaluate in vivo cestocidal activity of root tuber extract of C baccans and its active component resveratrol against the zoonotic cestode Hymenolepis diminuta in the experimental model rat The cestocidal activity was determined by monitoring the eggs per gram EPG counts in faeces of different treated groups The result showed that the highest dose of the plant extract 50 mg/kg and resveratrol 4564 mg/kg body weight has significant anthelmintic efficacy against H diminuta Crude extract of the plant as well as resveratrol reduced EPG count 56012 and 46049 and also resulted in decreased worm burden by 44287 and 31034 respectively The efficacy of the crude extract and resveratrol can be compared to the reference drug praziquantel The results exhibits considerable cestocidal potential of root tuber crude extract of C baccans and resveratrol and justify its folklore use
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