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Title of Journal: Parasitol Res

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Abbravation: Parasitology Research

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Springer-Verlag

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10.1016/0260-6917(93)90094-i

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1432-1955

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Tegumental surface changes in adultEmphasis Type=

Authors: Norma Rivera Froylán Ibarra Armando Zepeda Teresa Fortoul Alicia Hernández Rafael Castillo Germinal Cantó
Publish Date: 2004/05/25
Volume: 93, Issue: 4, Pages: 283-286
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Abstract

Our objective was to determine by scanning electron microscopy the structural changes in the tegument of adult Fasciola hepatica after treatment with 5chloro2methylthio61naphtyloxy1Hbenzimidazole called compound alpha and its active metabolite sulphoxide under in vitro and in vivo conditions For the in vitro studies flukes from sheep were exposed to 40 mg/l of compound alphasulphoxide over different incubation times Flukes for the in vivo studies were raised in sheep treated orally with compound alpha and killed at different times posttreatment Nontreated controls were included for each time of incubation The results showed lesions after 6 h of treatment such as swelling and furrows At 12 h the spines appeared to be surrounded by the tegument At 24 h the tegument in some areas showed an exposed basal lamina These changes became more severe as the incubation periods of the treated flukes increased Compound alpha exerts a significant effect on the tegument of F hepatica

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