Authors: ChunHsiang Chen YeouLih Huang ChuanMin Yen
Publish Date: 2004/07/31
Volume: 94, Issue: 1, Pages: 74-81
Abstract
BALB/cByJ mice were divided into zincdeficient ZD high zincsupplemented ZH adequately zincreplete ZA and normal control groups by daily dietary control The body weight in ZD and ZH mice became significantly less than that of normal control mice from 4 weeks P0002 until 7 weeks P00001 after consecutive zinc control The kinetics of change in body weight of ZD and ZH mice after infection with Angiostrongylus cantonensis were similar to that of uninfected groups mentioned above The worms recovered at days 7 14 and 21 after infection from ZD and ZH mice were significantly more in number than that in control mice P001 However the worms from day 21 after infection were shorter in size than those in control mice P001 The production of interleukin IL5 was significantly depressed in cultured spleen cells from uninfected and infected ZD and ZH mice compared with that from respective control group P≤002 Furthermore significantly lower eosinophil counts were observed in the cerebral spinal fluidCSF of ZD and ZH mice 3 weeks after infection than in the CSF of control mice P0001 The levels of immunoglobulins IgG IgM IgA and IgE in the supernatant of cultivated spleen cells and serum from ZD and ZH mice were all lower than those of control mice Thus the level of zinc correlated with the defence against infection by A cantonensis due to the influence of zinc on the growth of mice and their production of IL5 eosinophils and immunoglobulinsWe thank Miss LeeYi Chung for her help in the recovery of worms from the brains of infected mice This study was supported by grant MH91032 from the Mei Ho Institute of Technology Taiwan Republic of China The use of animals in this study was reviewed and permitted by the Committee of the Care and Use of Laboratory Animals Kaohsiung Medical University according to Taiwanese laws
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