Authors: Mohamed A Dkhil Abdel Azeem S AbdelBaki Frank Wunderlich Helmut Sies Saleh AlQuraishy
Publish Date: 2013/11/13
Volume: 113, Issue: 1, Pages: 267-274
Abstract
Here we investigated the effect of the trace element selenium Se on course and outcome of Eimeriapaplllatainduced coccidiosis in mice Male mice were fed on Seadequate 015 ppm Sedeficient and Sehigh diets 10 ppm for 6 weeks Mice were orally infected with 1000 oocysts The prepatent period lasts for 3 days but the course of infections varied At Seadequate diet the maximum fecal output of oocysts amounted to 68300 ooccysts/g feces on day 5 pi However fecal shedding of oocysts was accelerated in mice on Sedeficient diet and occurred already on day 4 pi By contrast maximal shedding is impaired in mice on highSe diet which takes place on day 5 pi but with a decreased output of only 7300 oocysts/g feces Light microscopy reveals that all developmental stages are affected meronts micro and macrogamonts and developing oocysts are increased in comparison with mice fed on seleniumadequate diet At high Se the number of parasitic stages in the jejunum is substantially higher than at Sedeficient diet Se does not affect the number of jejunal Alcian bluestained goblet cells Se deficiency increased the number of apoptotic cells in the jejunum Substantially increased histological injury scores reveal more injuries in jejunum tissue infected by E papillata Our data indicate that high dietary Se exerts potential anticoccidial activity This may be taken advantage of in control measures towards Eimeriosis as a feed additive potentially alleviating the need for concomitantly utilized anticoccidial drugs in the feed
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