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Title of Journal: Parasitol Res

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Abbravation: Parasitology Research

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Springer-Verlag

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1432-1955

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Immunomodulatory effect of R848 on cytokine produc

Authors: Ghada Boghdadi Dalia Abdel Khalik Sami Abdel Wahab Adel Farghaly
Publish Date: 2012/09/20
Volume: 112, Issue: 1, Pages: 135-140
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Abstract

This work aimed to determine the effect of resiquimod R848 a low molecular weight imidazoquinolinamine compound with properties as immune response modifiers on cytokine production in patients infected with Schistosoma mansoni with various degrees of hepatic fibrosis Schistosomainfected patients were classified into four groups according to the degree of hepatic fibrosis as examined by ultrasonography group 0 no fibrosis group I incipient fibrosis group II moderate fibrosis and group III severe fibrosis Levels of interferonγ IFNγ interleukin 4 IL4 IL10 and IL13 were measured by ELISA in the supernatants of cultured peripheral blood mononuclear cells PBMC in response to schistosoma egg soluble antigen SEA in the presence and absence of R848 R848 induced a significantly higher level of IL10 in supernatants of SEAstimulated PBMC of patients in all groups of hepatic fibrosis except group III Moreover we significantly found higher levels of IFNγ in group 0 and group I and significantly lower level of IL4 in group 0 after R848 stimulation However R848 had no effect on IL13 Taken together these results suggest that R848 might be used as an immunopotentiating agent in view of novel therapy or vaccine for S mansoni infection

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