Authors: L J Moran C Meyer S K Hutchison S Zoungas H J Teede
Publish Date: 2009/10/15
Volume: 33, Issue: 4, Pages: 258-265
Abstract
Background Polycystic ovary syndrome PCOS is associated with reproductive and metabolic abnormalities Aim The aim of this study was to assess novel inflammatory markers adipokines leptin adiponectin and leptinadiponectin ratio L/A in overweight women with and without PCOS and to examine alterations in these markers aldosterone leptin adiponectin and L/A with pharmacological interventions modulating insulin resistance IR in PCOS Materials/subjects and methods Overweight age and body mass index BMImatched women with no=80 or without PCOS no=27 were assessed crosssectionally Subjects with PCOS were then randomised to 6 months metformin 1 g bd no=26 or oral contraceptive pill OCP 35 g ethinyl estradiol/2 mg cytoproterone acetate no=30 Outcome measures were leptin adiponectin L/A aldosterone highly sensitive Creactive protein lipid profile IR and androgen levels Results Leptin levels were lower 1564±859 vs 2085±1052 ng/ml p=0015 while adiponectin and L/A were not different between women with and without PCOS Following intervention IR increased for the OCP and decreased for metformin however leptin and aldosterone decreased equivalently with the OCP and metformin with no difference between each treatment p=0583 and p=0801 respectively There was no change in adiponectin or L/A with the OCP or metformin On multiple regression the only baseline predictor of leptin was BMI r2=0485 p0001 and the strongest predictor of change in leptin was change in weight r2=0402 p0001 Conclusions Alterations in leptin between women with and without PCOS and following pharmacological interventions are primarily related to adiposity and not IR Aldosterone was reduced equivalently with metformin and the OCP despite differential effects on IR
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