Authors: S Zacharieva M Orbetzova A Stoynev R Shigarminova M Yaneva K Kalinov E Nachev A Elenkova
Publish Date: 2014/04/02
Volume: 27, Issue: 10, Pages: 924-930
Abstract
The aim of the study was to evaluate the circadian blood pressure BP pro files in patients with two forms of Cushing’s syndrome and to compare them to those in patients with essential hypertension The study included 100 patients with Cushing’s syndrome 80 with pituitary adenomas and 20 with adrenal adenomas and 40 with essential hypertension Twentyfour h ambulatory BP monitoring was performed before and after therapy All 3 groups had similar office 24 h awake and sleep BP mean values The awakesleep differences between the patients with two forms of Cushing’s syndrome were similar The nighttime BP decline in the patients with Cushing’s disease as well as in those with adrenal adenomas was significantly lower than that in the patients with essential hyperten sion In the patients with both forms of Cushing’s syndrome there was a highly significant decline in the office and ambulatory BP levels after the treatment and the awake sleep systolic BP difference became significantly higher The nighttime diastolic BP decline was significantly higher after treatment in patients with adrenal adenomas and notsignificantly higher in patients with Cushing’s disease In the patients with Cushing’s disease the duration of hypertension was greater and lower percentage of normalized BP after treatment was observed in comparison with the patients with adrenal adenomas The significant negative correlation between duration of the disease and extent of the nighttime BP decline suggests that the ‚non — dipping’ profile is related not only to hypercortisolism itself but also to the severity of hypertension and duration of the disease
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