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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1007/s10549-010-1100-z

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1720-8386

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Effects of gonadotropinreleasing hormone GnRH o

Authors: G Soldani M Del Tacca G Bambini A Polloni C Bemardini E Martinotti E Martino
Publish Date: 2014/04/11
Volume: 5, Issue: 6, Pages: 393-396
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Abstract

The effects of GnRH on gastric secretion and gastrin release from dogs provided with gastric fistulae and Heidenhain pouches have been investigated A transient yet significant inhibition of pentagastrinstimulated secretion from gastric fistulae was observed while secretion from Heidenhain pouches was unchanged The maximal inhibitory effect of GnRH on both acid and pepsin secretion stimulated by 2deoxyDglucose was obtained from gastric fistulae On the contrary GnRH failed to affect either acid secretion stimulated by bethanechol or acid secretion and gastrin release induced by bombesin The present results indicate that GnRH possesses an inhibitory action on gastric secretion from the vagally innervated stomach of the dog The most likely inhibitory mechanism seems to be represented by a decrease of the vagal activity

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