Authors: Hajime Watanobe S Sasaki K Takebe
Publish Date: 2014/04/01
Volume: 14, Issue: 10, Pages: 875-879
Abstract
Accumulating evidence suggests that vasoactive intestinal peptide VIP may be a physiological PRLreleasing factor In the present study we examined a possible involvement of VIP in the neonatal androgenization NAinduced hyperprolactinemia Twentyfour hours after birth newborn female rats were injected sc with 1000 µg of testosterone NA or with oil vehicle only control Both groups were sacrificed at 8 weeks of age Compared to controls NA rats showed significantly higher plasma PRL levels 73 fold anterior pituitary AP PRL content 21 fold and plasma estradiol levels 21 fold AP VIP content was extremely higher 61 fold in NA rats than in controls However NA did not affect VIP content in the suprachiasmatic nucleus paraventricular nucleus or median eminence These results suggest that the NAinduced hyperprolactinemia may be mediated at least in part by paracrine and/or autocrine effects of the increased AP VIP on PRL secretion However since the potentiation by NA of the AP VIP content was extremely marked compared to those of the other parameters the possibility was also raised that the increased AP VIP may be involved in other endocrine and/or nonendocrine events occurring in the AP
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